Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Psed_2148PFAM: Haloacid dehalogenase-like hydrolase; KEGG: sma:SAV_4277 hypothetical protein. (243 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.975
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.921
glyA-2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.921
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
 0.921
Psed_1785
KEGG: hoh:Hoch_1789 serine--pyruvate transaminase; PFAM: Aminotransferase, class V/Cysteine desulfurase.
   
 0.920
Psed_0938
TIGRFAM: Cystathionine beta-synthase; KEGG: sen:SACE_0899 cystathionine beta-synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cystathionine beta-synthase, core.
    
 0.913
Psed_2549
L-serine dehydratase 1; TIGRFAM: Iron-sulphur-dependent L-serine dehydratase single chain form; KEGG: rop:ROP_15050 L-serine dehydratase; PFAM: Serine dehydratase-like, alpha subunit; Serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family.
   
 
 0.911
Psed_3099
Cysteine synthase; KEGG: rha:RHA1_ro00594 cystathionine beta-synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
    
 0.907
Psed_0941
KEGG: svi:Svir_31840 threonine dehydratase; TIGRFAM: Threonine dehydratase II; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Amino acid-binding ACT.
    
 0.906
Psed_1496
TIGRFAM: Phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: sen:SACE_1188 phosphoserine phosphatase; PFAM: Haloacid dehalogenase-like hydrolase; Amino acid-binding ACT.
    
 0.906
Your Current Organism:
Pseudonocardia dioxanivorans
NCBI taxonomy Id: 675635
Other names: P. dioxanivorans CB1190, Pseudonocardia dioxanivorans CB1190, Pseudonocardia dioxanivorans DSM 44775, Pseudonocardia dioxanivorans str. CB1190, Pseudonocardia dioxanivorans strain CB1190
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