| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Psed_0209 | arc | Psed_0209 | Psed_3319 | PFAM: Protein of unknown function DUF2587; KEGG: ami:Amir_0135 hypothetical protein. | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.832 |
| Psed_0209 | pafA | Psed_0209 | Psed_3293 | PFAM: Protein of unknown function DUF2587; KEGG: ami:Amir_0135 hypothetical protein. | Proteasome accessory factor PafA; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.744 |
| Psed_0209 | prcA | Psed_0209 | Psed_3303 | PFAM: Protein of unknown function DUF2587; KEGG: ami:Amir_0135 hypothetical protein. | Proteasome, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.976 |
| Psed_0209 | prcB | Psed_0209 | Psed_3304 | PFAM: Protein of unknown function DUF2587; KEGG: ami:Amir_0135 hypothetical protein. | Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.917 |
| Psed_0209 | pup | Psed_0209 | Psed_3305 | PFAM: Protein of unknown function DUF2587; KEGG: ami:Amir_0135 hypothetical protein. | Ubiquitin-like protein pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.682 |
| Psed_2142 | Psed_6507 | Psed_2142 | Psed_6507 | KEGG: ami:Amir_1335 hypothetical protein. | KEGG: ami:Amir_0253 transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp; SMART: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp. | 0.657 |
| Psed_2142 | arc | Psed_2142 | Psed_3319 | KEGG: ami:Amir_1335 hypothetical protein. | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.581 |
| Psed_2142 | pafA | Psed_2142 | Psed_3293 | KEGG: ami:Amir_1335 hypothetical protein. | Proteasome accessory factor PafA; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.615 |
| Psed_3294 | pafA | Psed_3294 | Psed_3293 | Phosphoesterase PA-phosphatase related protein; KEGG: sen:SACE_2253 putative glycerophosphatase; PFAM: Phosphatidic acid phosphatase type 2/haloperoxidase; Diacylglycerol kinase, catalytic domain; SMART: Phosphatidic acid phosphatase type 2/haloperoxidase; Diacylglycerol kinase, catalytic domain. | Proteasome accessory factor PafA; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.616 |
| Psed_3321 | arc | Psed_3321 | Psed_3319 | KEGG: sen:SACE_2242 RecB family exonuclease. | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.618 |
| Psed_3321 | pafA | Psed_3321 | Psed_3293 | KEGG: sen:SACE_2242 RecB family exonuclease. | Proteasome accessory factor PafA; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.569 |
| Psed_6507 | Psed_2142 | Psed_6507 | Psed_2142 | KEGG: ami:Amir_0253 transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp; SMART: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp. | KEGG: ami:Amir_1335 hypothetical protein. | 0.657 |
| Psed_6507 | arc | Psed_6507 | Psed_3319 | KEGG: ami:Amir_0253 transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp; SMART: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp. | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.423 |
| Psed_6507 | pafA | Psed_6507 | Psed_3293 | KEGG: ami:Amir_0253 transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp; SMART: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp. | Proteasome accessory factor PafA; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.581 |
| arc | Psed_0209 | Psed_3319 | Psed_0209 | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | PFAM: Protein of unknown function DUF2587; KEGG: ami:Amir_0135 hypothetical protein. | 0.832 |
| arc | Psed_2142 | Psed_3319 | Psed_2142 | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | KEGG: ami:Amir_1335 hypothetical protein. | 0.581 |
| arc | Psed_3321 | Psed_3319 | Psed_3321 | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | KEGG: sen:SACE_2242 RecB family exonuclease. | 0.618 |
| arc | Psed_6507 | Psed_3319 | Psed_6507 | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | KEGG: ami:Amir_0253 transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp; SMART: Cyclic nucleotide-binding domain; HTH transcriptional regulator, Crp. | 0.423 |
| arc | pafA | Psed_3319 | Psed_3293 | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | Proteasome accessory factor PafA; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.938 |
| arc | panB | Psed_3319 | Psed_3970 | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.566 |
