Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Psed_3370Enoyl-(acyl-carrier-protein) reductase (NADH); KEGG: sen:SACE_3786 enoyl-(acyl carrier protein) reductase. (258 aa)    
Predicted Functional Partners:
Psed_2963
Acetyl-CoA carboxylase; KEGG: nda:Ndas_2606 carboxyl transferase; PFAM: Carboxyl transferase.
  
  
 0.989
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
 
 
 0.969
Psed_2137
(Acyl-carrier-protein) S-malonyltransferase; PFAM: Acyl transferase; KEGG: rha:RHA1_ro01199 [acyl-carrier protein] S-malonyltransferase; SMART: Polyketide synthase, acyl transferase domain.
 
  
 0.939
fabH
3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
  
 0.925
Psed_2134
Beta-ketoacyl-acyl-carrier-protein synthase I; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
  
 0.910
Psed_0508
Beta-ketoacyl-acyl-carrier-protein synthase II; PFAM: Beta-ketoacyl synthase, N-terminal; Beta-ketoacyl synthase, C-terminal; KEGG: nca:Noca_4118 beta-ketoacyl synthase; SMART: Polyketide synthase, beta-ketoacyl synthase domain; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
  
 0.897
Psed_2738
PFAM: 4'-phosphopantetheinyl transferase; KEGG: kfl:Kfla_4144 4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily.
  
  
 0.873
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
   
 0.845
Psed_3371
3-oxoacyl-(acyl-carrier-protein) reductase; SMART: Polyketide synthase/Fatty acid synthase, KR; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; KEGG: gob:Gobs_2104 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: Short-chain dehydrogenase/reductase SDR.
 
  
 0.793
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.714
Your Current Organism:
Pseudonocardia dioxanivorans
NCBI taxonomy Id: 675635
Other names: P. dioxanivorans CB1190, Pseudonocardia dioxanivorans CB1190, Pseudonocardia dioxanivorans DSM 44775, Pseudonocardia dioxanivorans str. CB1190, Pseudonocardia dioxanivorans strain CB1190
Server load: low (16%) [HD]