| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX35652.1 | EEX36578.1 | VIB_003021 | VIB_000679 | DNA polymerase III beta subunit. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.950 |
| EEX35652.1 | EEX37260.1 | VIB_003021 | VIB_001380 | DNA polymerase III beta subunit. | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.810 |
| EEX35652.1 | tdk | VIB_003021 | VIB_001116 | DNA polymerase III beta subunit. | Thymidine kinase. | 0.404 |
| EEX35652.1 | thyA | VIB_003021 | VIB_000227 | DNA polymerase III beta subunit. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.812 |
| EEX36023.1 | EEX37962.1 | VIB_002336 | VIB_002094 | Aminomethyltransferase (glycine cleavage system T protein). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.672 |
| EEX36023.1 | fmt | VIB_002336 | VIB_003036 | Aminomethyltransferase (glycine cleavage system T protein). | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.708 |
| EEX36023.1 | thyA | VIB_002336 | VIB_000227 | Aminomethyltransferase (glycine cleavage system T protein). | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.850 |
| EEX36438.1 | EEX37962.1 | VIB_002753 | VIB_002094 | Putative deoxycytidylate deaminase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.779 |
| EEX36438.1 | tdk | VIB_002753 | VIB_001116 | Putative deoxycytidylate deaminase. | Thymidine kinase. | 0.714 |
| EEX36438.1 | thyA | VIB_002753 | VIB_000227 | Putative deoxycytidylate deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.791 |
| EEX36438.1 | tmk | VIB_002753 | VIB_001609 | Putative deoxycytidylate deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.709 |
| EEX36578.1 | EEX35652.1 | VIB_000679 | VIB_003021 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA polymerase III beta subunit. | 0.950 |
| EEX36578.1 | EEX37260.1 | VIB_000679 | VIB_001380 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.516 |
| EEX36578.1 | thyA | VIB_000679 | VIB_000227 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.763 |
| EEX36578.1 | tmk | VIB_000679 | VIB_001609 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.485 |
| EEX37260.1 | EEX35652.1 | VIB_001380 | VIB_003021 | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase III beta subunit. | 0.810 |
| EEX37260.1 | EEX36578.1 | VIB_001380 | VIB_000679 | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.516 |
| EEX37260.1 | tdk | VIB_001380 | VIB_001116 | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidine kinase. | 0.463 |
| EEX37260.1 | thyA | VIB_001380 | VIB_000227 | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.871 |
| EEX37260.1 | tmk | VIB_001380 | VIB_001609 | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.777 |