STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEX38354.1Aconitate hydratase 2; Enzyme with broad specificity; 2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (865 aa)    
Predicted Functional Partners:
EEX36753.1
Pyruvate-flavodoxin oxidoreductase.
   
 
 0.941
EEX36698.1
Citrate synthase (si); Belongs to the citrate synthase family.
  
 
 0.932
sucC
succinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.921
EEX37222.1
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 
 0.918
EEX36979.1
Isocitrate dehydrogenase [NADP]; Most likely function alternative not yet resolved; monomeric isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family.
 
 
 0.898
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
  
 0.859
prpB
Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
    
 0.827
EEX36701.1
2-oxoglutarate dehydrogenase E1 component.
   
  
 0.813
EEX37220.1
PrpF protein involved in 2-methylcitrate cycle.
    
 0.806
EEX37238.1
Fumarate hydratase class I aerobic.
  
  
 0.804
Your Current Organism:
Vibrio metschnikovii
NCBI taxonomy Id: 675813
Other names: V. metschnikovii CIP 69.14, Vibrio metschnikovii CIP 69.14, Vibrio metschnikovii str. CIP 69.14, Vibrio metschnikovii strain CIP 69.14
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