| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX35659.1 | EEX37817.1 | VIB_003028 | VIB_001945 | Signal transduction histidine kinase. | Glutamate synthase [NADPH] large chain. | 0.479 |
| EEX35659.1 | EEX38394.1 | VIB_003028 | VIB_000340 | Signal transduction histidine kinase. | Methyl-accepting chemotaxis protein. | 0.849 |
| EEX35659.1 | glnE | VIB_003028 | VIB_000339 | Signal transduction histidine kinase. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.475 |
| EEX36645.1 | glnE | VIB_000750 | VIB_000339 | Thiol peroxidase Bcp-type. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.478 |
| EEX37113.1 | argA | VIB_001227 | VIB_001901 | ATP-dependent helicase HrpA. | Acetylglutamate kinase; COG0548. | 0.462 |
| EEX37113.1 | glnE | VIB_001227 | VIB_000339 | ATP-dependent helicase HrpA. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.534 |
| EEX37817.1 | EEX35659.1 | VIB_001945 | VIB_003028 | Glutamate synthase [NADPH] large chain. | Signal transduction histidine kinase. | 0.479 |
| EEX37817.1 | EEX38028.1 | VIB_001945 | VIB_000397 | Glutamate synthase [NADPH] large chain. | Glutamine synthetase type I. | 0.987 |
| EEX37817.1 | argA | VIB_001945 | VIB_001901 | Glutamate synthase [NADPH] large chain. | Acetylglutamate kinase; COG0548. | 0.673 |
| EEX37817.1 | glnD | VIB_001945 | VIB_000663 | Glutamate synthase [NADPH] large chain. | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.611 |
| EEX37817.1 | glnE | VIB_001945 | VIB_000339 | Glutamate synthase [NADPH] large chain. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.518 |
| EEX38028.1 | EEX37817.1 | VIB_000397 | VIB_001945 | Glutamine synthetase type I. | Glutamate synthase [NADPH] large chain. | 0.987 |
| EEX38028.1 | argA | VIB_000397 | VIB_001901 | Glutamine synthetase type I. | Acetylglutamate kinase; COG0548. | 0.463 |
| EEX38028.1 | glnD | VIB_000397 | VIB_000663 | Glutamine synthetase type I. | [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.536 |
| EEX38028.1 | glnE | VIB_000397 | VIB_000339 | Glutamine synthetase type I. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.761 |
| EEX38394.1 | EEX35659.1 | VIB_000340 | VIB_003028 | Methyl-accepting chemotaxis protein. | Signal transduction histidine kinase. | 0.849 |
| EEX38394.1 | glnE | VIB_000340 | VIB_000339 | Methyl-accepting chemotaxis protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.576 |
| EEX38394.1 | hldE | VIB_000340 | VIB_000338 | Methyl-accepting chemotaxis protein. | ADP-heptose synthase/D-glycero-beta-D-manno-heptose 7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.425 |
| argA | EEX37113.1 | VIB_001901 | VIB_001227 | Acetylglutamate kinase; COG0548. | ATP-dependent helicase HrpA. | 0.462 |
| argA | EEX37817.1 | VIB_001901 | VIB_001945 | Acetylglutamate kinase; COG0548. | Glutamate synthase [NADPH] large chain. | 0.673 |