Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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gene co-occurrence
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EEX38421.1Sigma factor RpoE negative regulatory protein RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytop [...] (212 aa)    
Predicted Functional Partners:
EEX38420.1
Sigma factor RpoE negative regulatory protein RseB precursor.
 
 
 0.999
EEX38422.1
RNA polymerase sigma factor RpoE; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.997
EEX37859.1
Outer membrane stress sensor protease DegS.
  
 
 0.943
EEX37766.1
RNA polymerase sigma-70 factor ECF subfamily.
  
 
 0.926
EEX37858.1
Outer membrane stress sensor protease DegQ; Belongs to the peptidase S1C family.
  
 
 0.902
EEX35831.1
DNA-directed RNA polymerase specialized sigma subunit.
  
 
 0.881
EEX37851.1
Stringent starvation protein B.
    
 
 0.858
bamC
NlpB lipoprotein component of the protein assembly complex; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
     0.719
zapC
Hypothetical protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
  
     0.693
rraB
Hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
   
 0.691
Your Current Organism:
Vibrio metschnikovii
NCBI taxonomy Id: 675813
Other names: V. metschnikovii CIP 69.14, Vibrio metschnikovii CIP 69.14, Vibrio metschnikovii str. CIP 69.14, Vibrio metschnikovii strain CIP 69.14
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