| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX36023.1 | EEX36767.1 | VIB_002336 | VIB_000873 | Aminomethyltransferase (glycine cleavage system T protein). | Formyltetrahydrofolate deformylase. | 0.897 |
| EEX36023.1 | EEX38006.1 | VIB_002336 | VIB_002140 | Aminomethyltransferase (glycine cleavage system T protein). | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.958 |
| EEX36023.1 | fhs | VIB_002336 | VIB_002342 | Aminomethyltransferase (glycine cleavage system T protein). | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.922 |
| EEX36023.1 | folD | VIB_002336 | VIB_001672 | Aminomethyltransferase (glycine cleavage system T protein). | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.973 |
| EEX36023.1 | glyA | VIB_002336 | VIB_001745 | Aminomethyltransferase (glycine cleavage system T protein). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.999 |
| EEX36023.1 | purD | VIB_002336 | VIB_002874 | Aminomethyltransferase (glycine cleavage system T protein). | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.615 |
| EEX36023.1 | purH | VIB_002336 | VIB_002873 | Aminomethyltransferase (glycine cleavage system T protein). | IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.920 |
| EEX36023.1 | purN | VIB_002336 | VIB_000697 | Aminomethyltransferase (glycine cleavage system T protein). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.896 |
| EEX36767.1 | EEX36023.1 | VIB_000873 | VIB_002336 | Formyltetrahydrofolate deformylase. | Aminomethyltransferase (glycine cleavage system T protein). | 0.897 |
| EEX36767.1 | EEX36844.1 | VIB_000873 | VIB_000951 | Formyltetrahydrofolate deformylase. | Pyruvate formate-lyase. | 0.882 |
| EEX36767.1 | EEX38006.1 | VIB_000873 | VIB_002140 | Formyltetrahydrofolate deformylase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.891 |
| EEX36767.1 | fhs | VIB_000873 | VIB_002342 | Formyltetrahydrofolate deformylase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.936 |
| EEX36767.1 | folD | VIB_000873 | VIB_001672 | Formyltetrahydrofolate deformylase. | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.976 |
| EEX36767.1 | glyA | VIB_000873 | VIB_001745 | Formyltetrahydrofolate deformylase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |
| EEX36767.1 | purD | VIB_000873 | VIB_002874 | Formyltetrahydrofolate deformylase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.958 |
| EEX36767.1 | purH | VIB_000873 | VIB_002873 | Formyltetrahydrofolate deformylase. | IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.905 |
| EEX36767.1 | purM | VIB_000873 | VIB_000698 | Formyltetrahydrofolate deformylase. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.941 |
| EEX36767.1 | purN | VIB_000873 | VIB_000697 | Formyltetrahydrofolate deformylase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.903 |
| EEX36844.1 | EEX36767.1 | VIB_000951 | VIB_000873 | Pyruvate formate-lyase. | Formyltetrahydrofolate deformylase. | 0.882 |
| EEX38006.1 | EEX36023.1 | VIB_002140 | VIB_002336 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase (glycine cleavage system T protein). | 0.958 |