| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX36023.1 | folD | VIB_002336 | VIB_001672 | Aminomethyltransferase (glycine cleavage system T protein). | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.919 |
| EEX36023.1 | glyA | VIB_002336 | VIB_001745 | Aminomethyltransferase (glycine cleavage system T protein). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| EEX36023.1 | rlmI | VIB_002336 | VIB_001204 | Aminomethyltransferase (glycine cleavage system T protein). | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | 0.470 |
| EEX36978.1 | rlmI | VIB_001087 | VIB_001204 | Ribosomal large subunit pseudouridine synthase E; Belongs to the pseudouridine synthase RsuA family. | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | 0.430 |
| EEX37572.1 | folD | VIB_001697 | VIB_001672 | Dihydrofolate synthase/folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.524 |
| EEX37572.1 | glyA | VIB_001697 | VIB_001745 | Dihydrofolate synthase/folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.726 |
| EEX37572.1 | rlmI | VIB_001697 | VIB_001204 | Dihydrofolate synthase/folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | 0.417 |
| folD | EEX36023.1 | VIB_001672 | VIB_002336 | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase (glycine cleavage system T protein). | 0.919 |
| folD | EEX37572.1 | VIB_001672 | VIB_001697 | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrofolate synthase/folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.524 |
| folD | glyA | VIB_001672 | VIB_001745 | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
| folD | rlmI | VIB_001672 | VIB_001204 | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | 0.430 |
| glyA | EEX36023.1 | VIB_001745 | VIB_002336 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase (glycine cleavage system T protein). | 0.995 |
| glyA | EEX37572.1 | VIB_001745 | VIB_001697 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrofolate synthase/folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.726 |
| glyA | folD | VIB_001745 | VIB_001672 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.935 |
| glyA | rlmI | VIB_001745 | VIB_001204 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | 0.440 |
| rlmI | EEX36023.1 | VIB_001204 | VIB_002336 | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | Aminomethyltransferase (glycine cleavage system T protein). | 0.470 |
| rlmI | EEX36978.1 | VIB_001204 | VIB_001087 | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | Ribosomal large subunit pseudouridine synthase E; Belongs to the pseudouridine synthase RsuA family. | 0.430 |
| rlmI | EEX37572.1 | VIB_001204 | VIB_001697 | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | Dihydrofolate synthase/folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.417 |
| rlmI | folD | VIB_001204 | VIB_001672 | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.430 |
| rlmI | glyA | VIB_001204 | VIB_001745 | Hypothetical protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.440 |