def-2 protein (Vibrio metschnikovii) - STRING interaction network

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def-2

Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (170 aa)

Predicted Functional Partners:

fmt

0.950

rplV

0.887

rplQ

0.875

rpsJ

0.873

rplT

0.869

rpsP

0.863

rplD

0.861

rplU

0.861

rplI

0.859

rpmA

0.851

Your Current Organism:

Vibrio metschnikovii

NCBI taxonomy Id: 675813
Other names: V. metschnikovii CIP 69.14, Vibrio metschnikovii CIP 69.14, Vibrio metschnikovii str. CIP 69.14, Vibrio metschnikovii strain CIP 69.14

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
def-2	fmt	VIB_003035	VIB_003036	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	0.950
def-2	rplD	VIB_003035	VIB_000539	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	0.861
def-2	rplI	VIB_003035	VIB_002153	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	LSU ribosomal protein L9p; Binds to the 23S rRNA.	0.859
def-2	rplQ	VIB_003035	VIB_000564	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	LSU ribosomal protein L17p.	0.875
def-2	rplT	VIB_003035	VIB_002781	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	LSU ribosomal protein L20p; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.869
def-2	rplU	VIB_003035	VIB_002099	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	LSU ribosomal protein L21p; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.861
def-2	rplV	VIB_003035	VIB_000543	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	LSU ribosomal protein L22p (L17e); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.887
def-2	rpmA	VIB_003035	VIB_002098	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	LSU ribosomal protein L27p; Belongs to the bacterial ribosomal protein bL27 family.	0.851
def-2	rpsJ	VIB_003035	VIB_000537	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	SSU ribosomal protein S10p (S20e); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.873
def-2	rpsP	VIB_003035	VIB_001991	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	SSU ribosomal protein S16p; Belongs to the bacterial ribosomal protein bS16 family.	0.863
fmt	def-2	VIB_003036	VIB_003035	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.950
fmt	rplU	VIB_003036	VIB_002099	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	LSU ribosomal protein L21p; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.479
fmt	rpsJ	VIB_003036	VIB_000537	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	SSU ribosomal protein S10p (S20e); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.449
rplD	def-2	VIB_000539	VIB_003035	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.861
rplD	rplI	VIB_000539	VIB_002153	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	LSU ribosomal protein L9p; Binds to the 23S rRNA.	0.997
rplD	rplQ	VIB_000539	VIB_000564	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	LSU ribosomal protein L17p.	0.998
rplD	rplT	VIB_000539	VIB_002781	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	LSU ribosomal protein L20p; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.997
rplD	rplU	VIB_000539	VIB_002099	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	LSU ribosomal protein L21p; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.995
rplD	rplV	VIB_000539	VIB_000543	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	LSU ribosomal protein L22p (L17e); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.999
rplD	rpmA	VIB_000539	VIB_002098	LSU ribosomal protein L4p (L1e); Forms part of the polypeptide exit tunnel.	LSU ribosomal protein L27p; Belongs to the bacterial ribosomal protein bL27 family.	0.995

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