node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEX93301.1 | EEX95176.1 | VIA_003948 | VIA_000639 | Acetolactate synthase large subunit. | Acetolactate synthase large subunit. | 0.679 |
EEX93301.1 | ilvA | VIA_003948 | VIA_000643 | Acetolactate synthase large subunit. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.915 |
EEX93301.1 | ilvC | VIA_003948 | VIA_000102 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.973 |
EEX93301.1 | ilvH | VIA_003948 | VIA_003947 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.999 |
EEX93301.1 | leuA | VIA_003948 | VIA_003954 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.942 |
EEX93301.1 | leuB | VIA_003948 | VIA_003955 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.953 |
EEX93301.1 | leuC | VIA_003948 | VIA_003956 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.915 |
EEX93301.1 | leuD | VIA_003948 | VIA_003957 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.929 |
EEX93301.1 | metL | VIA_003948 | VIA_004176 | Acetolactate synthase large subunit. | Aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.760 |
EEX93301.1 | thrA | VIA_003948 | VIA_003897 | Acetolactate synthase large subunit. | Aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.760 |
EEX95176.1 | EEX93301.1 | VIA_000639 | VIA_003948 | Acetolactate synthase large subunit. | Acetolactate synthase large subunit. | 0.679 |
EEX95176.1 | ilvA | VIA_000639 | VIA_000643 | Acetolactate synthase large subunit. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.977 |
EEX95176.1 | ilvC | VIA_000639 | VIA_000102 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.973 |
EEX95176.1 | ilvH | VIA_000639 | VIA_003947 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.998 |
EEX95176.1 | leuA | VIA_000639 | VIA_003954 | Acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.945 |
EEX95176.1 | leuB | VIA_000639 | VIA_003955 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.955 |
EEX95176.1 | leuC | VIA_000639 | VIA_003956 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.914 |
EEX95176.1 | leuD | VIA_000639 | VIA_003957 | Acetolactate synthase large subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.922 |
EEX95176.1 | metL | VIA_000639 | VIA_004176 | Acetolactate synthase large subunit. | Aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.760 |
EEX95176.1 | thrA | VIA_000639 | VIA_003897 | Acetolactate synthase large subunit. | Aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.798 |