A0A1E3PVX8 protein (Lipomyces starkeyi) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1E3PVX8

Uncharacterized protein. (364 aa)

Predicted Functional Partners:

A0A1E3PZ42

0.790

A0A1E3Q0P4

0.790

A0A1E3Q1Y3

0.790

A0A1E3Q908

0.790

A0A1E3QD08

0.790

A0A1E3QDF7

0.790

A0A1E3PUG1

0.757

A0A1E3Q1J5

0.686

A0A1E3Q5R9

0.686

A0A1E3QBL5

0.686

Your Current Organism:

Lipomyces starkeyi

NCBI taxonomy Id: 675824
Other names: L. starkeyi NRRL Y-11557, Lipomyces starkeyi NRRL Y-11557

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1E3PUG1	A0A1E3PVX8	SH3 domain-containing protein.	Uncharacterized protein.	0.757
A0A1E3PUG1	A0A1E3PZ42	SH3 domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.556
A0A1E3PUG1	A0A1E3Q0P4	SH3 domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.548
A0A1E3PUG1	A0A1E3Q1J5	SH3 domain-containing protein.	Uncharacterized protein.	0.745
A0A1E3PUG1	A0A1E3Q1Y3	SH3 domain-containing protein.	Uncharacterized protein.	0.855
A0A1E3PUG1	A0A1E3Q5R9	SH3 domain-containing protein.	Uncharacterized protein.	0.745
A0A1E3PUG1	A0A1E3Q908	SH3 domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.548
A0A1E3PUG1	A0A1E3QBL5	SH3 domain-containing protein.	Uncharacterized protein.	0.745
A0A1E3PUG1	A0A1E3QD08	SH3 domain-containing protein.	Uncharacterized protein.	0.548
A0A1E3PUG1	A0A1E3QDF7	SH3 domain-containing protein.	PH domain-containing protein.	0.855
A0A1E3PVX8	A0A1E3PUG1	Uncharacterized protein.	SH3 domain-containing protein.	0.757
A0A1E3PVX8	A0A1E3PZ42	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.790
A0A1E3PVX8	A0A1E3Q0P4	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.790
A0A1E3PVX8	A0A1E3Q1J5	Uncharacterized protein.	Uncharacterized protein.	0.686
A0A1E3PVX8	A0A1E3Q1Y3	Uncharacterized protein.	Uncharacterized protein.	0.790
A0A1E3PVX8	A0A1E3Q5R9	Uncharacterized protein.	Uncharacterized protein.	0.686
A0A1E3PVX8	A0A1E3Q908	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.790
A0A1E3PVX8	A0A1E3QBL5	Uncharacterized protein.	Uncharacterized protein.	0.686
A0A1E3PVX8	A0A1E3QD08	Uncharacterized protein.	Uncharacterized protein.	0.790
A0A1E3PVX8	A0A1E3QDF7	Uncharacterized protein.	PH domain-containing protein.	0.790

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.724

expected number of edges:

14

PPI enrichment p-value:

2.45e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

11 of 692

1.68

4.1

2.54e-15

GO:0007212

Dopamine receptor signaling pathway

4 of 29

2.62

3.4

4.04e-07

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

3 of 7

3.12

3.03

3.11e-06

GO:1901699

Cellular response to nitrogen compound

6 of 361

1.7

2.42

9.63e-07

GO:0007188

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway

5 of 234

1.81

2.36

4.16e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031683

G-protein beta/gamma-subunit complex binding

5 of 25

2.78

4.94

5.04e-10

GO:0001664

G protein-coupled receptor binding

5 of 161

1.98

2.75

1.14e-06

GO:0030159

Signaling receptor complex adaptor activity

3 of 43

2.33

2.03

0.00014

GO:0044877

Protein-containing complex binding

8 of 1080

1.35

1.88

2.46e-07

GO:0003924

GTPase activity

5 of 342

1.65

1.88

3.43e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

9 of 33

2.92

11.15

2.10e-22

GO:0005886

Plasma membrane

11 of 4843

0.84

0.91

6.11e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36831

GTPase complex, and Prostanoid receptor

7 of 47

2.66

7.23

5.09e-15

CL:36820

Transducer, and G beta:gamma signalling through PLC beta

9 of 137

2.3

7.05

1.19e-16

CL:36824

Mixed, incl. GTPase complex, and Amine ligand-binding receptors

8 of 103

2.37

6.79

2.27e-15

CL:36832

GTPase complex, and Prostanoid receptor

5 of 33

2.66

4.98

2.94e-10

CL:36833

GTPase complex, and GPCR, family 2, latrophilin

4 of 24

2.71

3.88

5.28e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

7 of 174

2.09

4.78

7.85e-12

map04020

Calcium signaling pathway

5 of 350

1.64

2.1

5.78e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-202040

G-protein activation

7 of 20

3.03

8.66

4.99e-17

MAP-428930

Thromboxane signalling through TP receptor

7 of 21

3.01

8.64

4.99e-17

MAP-418592

ADP signalling through P2Y purinoceptor 1

7 of 22

2.99

8.62

4.99e-17

MAP-456926

Thrombin signalling through proteinase activated receptors (PARs)

7 of 29

2.87

8.3

1.17e-16

MAP-392518

Signal amplification

7 of 31

2.84

8.22

1.42e-16

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 12472

0.43

0.38

0.00017

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 9

3.13

4.46

6.96e-09

GOCC:0005886

Plasma membrane

8 of 2309

1.02

1.08

1.37e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0807

Transducer

6 of 315

1.76

2.8

1.02e-07

KW-0342

GTP-binding

4 of 184

1.82

1.99

4.78e-05

KW-0853

WD repeat

4 of 261

1.67

1.7

0.00013

KW-0677

Repeat

4 of 866

1.15

0.79

0.0080

KW-0175

Coiled coil

7 of 3975

0.73

0.53

0.0055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

4 of 4

3.48

4.7

3.16e-09

IPR001632

G-protein, beta subunit

4 of 5

3.39

4.69

3.16e-09

IPR011025

G protein alpha subunit, helical insertion

4 of 18

2.83

3.76

1.10e-07

IPR001019

Guanine nucleotide binding protein (G-protein), alpha subunit

4 of 20

2.78

3.72

1.20e-07

IPR020472

G-protein beta WD-40 repeat

4 of 77

2.2

2.45

1.49e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00275

G protein alpha subunit

4 of 19

2.81

3.96

4.29e-08

SM00320

WD40 repeats

4 of 283

1.63

1.43

0.00064

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