A0A1E3QE81 protein (Lipomyces starkeyi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1E3QE81

Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (289 aa)

Predicted Functional Partners:

A0A1E3QFF9

0.969

A0A1E3Q9T6

0.967

A0A1E3PWJ0

0.963

A0A1E3QD76

0.954

A0A1E3PV53

0.944

A0A1E3PV83

0.944

A0A1E3PVB1

0.944

A0A1E3QBN5

0.943

A0A1E3QD91

0.943

A0A1E3Q2G9

0.938

Your Current Organism:

Lipomyces starkeyi

NCBI taxonomy Id: 675824
Other names: L. starkeyi NRRL Y-11557, Lipomyces starkeyi NRRL Y-11557

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1E3PV53	A0A1E3PWJ0	Triosephosphate isomerase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.993
A0A1E3PV53	A0A1E3Q9T6	Triosephosphate isomerase.	Uncharacterized protein.	0.944
A0A1E3PV53	A0A1E3QBN5	Triosephosphate isomerase.	Uncharacterized protein.	0.949
A0A1E3PV53	A0A1E3QD76	Triosephosphate isomerase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.942
A0A1E3PV53	A0A1E3QD91	Triosephosphate isomerase.	Uncharacterized protein.	0.908
A0A1E3PV53	A0A1E3QE81	Triosephosphate isomerase.	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	0.944
A0A1E3PV53	A0A1E3QFF9	Triosephosphate isomerase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.976
A0A1E3PV83	A0A1E3PWJ0	Triosephosphate isomerase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.998
A0A1E3PV83	A0A1E3Q9T6	Triosephosphate isomerase.	Uncharacterized protein.	0.944
A0A1E3PV83	A0A1E3QBN5	Triosephosphate isomerase.	Uncharacterized protein.	0.953
A0A1E3PV83	A0A1E3QD76	Triosephosphate isomerase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.971
A0A1E3PV83	A0A1E3QD91	Triosephosphate isomerase.	Uncharacterized protein.	0.908
A0A1E3PV83	A0A1E3QE81	Triosephosphate isomerase.	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	0.944
A0A1E3PV83	A0A1E3QFF9	Triosephosphate isomerase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.996
A0A1E3PVB1	A0A1E3PWJ0	Triosephosphate isomerase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.993
A0A1E3PVB1	A0A1E3Q9T6	Triosephosphate isomerase.	Uncharacterized protein.	0.944
A0A1E3PVB1	A0A1E3QBN5	Triosephosphate isomerase.	Uncharacterized protein.	0.949
A0A1E3PVB1	A0A1E3QD76	Triosephosphate isomerase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.942
A0A1E3PVB1	A0A1E3QD91	Triosephosphate isomerase.	Uncharacterized protein.	0.908
A0A1E3PVB1	A0A1E3QE81	Triosephosphate isomerase.	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.	0.944

page 1 of 5

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000724

Double-strand break repair via homologous recombination

3 of 4

2.43

1.93

0.00054

GO:0006281

DNA repair

4 of 50

1.46

1.23

0.0020

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003690

Double-stranded DNA binding

3 of 14

1.89

1.25

0.0057

GO:0003678

DNA helicase activity

3 of 14

1.89

1.25

0.0057

GO:0004527

Exonuclease activity

3 of 20

1.73

1.2

0.0057

GO:0016887

ATP hydrolysis activity

3 of 41

1.42

0.86

0.0179

GO:0008408

3-5 exonuclease activity

2 of 9

1.9

0.86

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033202

DNA helicase complex

3 of 8

2.13

2.0

0.00027

GO:1902494

Catalytic complex

4 of 68

1.33

1.21

0.00092

GO:0032991

Protein-containing complex

5 of 170

1.03

0.88

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1230

PD-(D/E)XK nuclease superfamily, and CBS domain

4 of 6

2.38

3.11

3.40e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033202

DNA helicase complex

3 of 13

1.92

1.48

0.0020

GOCC:0044815

DNA packaging complex

3 of 15

1.86

1.46

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0269

Exonuclease

3 of 11

1.99

1.9

0.00033

KW-0234

DNA repair

4 of 31

1.67

1.72

0.00024

KW-0227

DNA damage

4 of 31

1.67

1.72

0.00024

KW-0347

Helicase

3 of 20

1.73

1.5

0.0012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13361

UvrD-like helicase C-terminal domain

3 of 3

2.56

2.31

0.00013

PF12705

PD-(D/E)XK nuclease superfamily

3 of 4

2.43

2.28

0.00013

PF13245

AAA domain

2 of 5

2.16

0.99

0.0212

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038726

PD-(D/E)XK endonuclease-like domain, AddAB-type

3 of 4

2.43

1.92

0.00058

IPR011604

PD-(D/E)XK endonuclease-like domain superfamily

3 of 4

2.43

1.92

0.00058

IPR011335

Restriction endonuclease type II-like

3 of 7

2.19

1.82

0.00067

IPR014016

UvrD-like helicase, ATP-binding domain

3 of 8

2.13

1.8

0.00068

IPR000212

DNA helicase, UvrD/REP type

3 of 8

2.13

1.8

0.00068

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About