A0A1E3QGG3 protein (Lipomyces starkeyi) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1E3QGG3

Uncharacterized protein. (1238 aa)

Predicted Functional Partners:

A0A1E3QG03

0.988

A0A1E3Q9V3

0.938

A0A1E3Q7Z0

0.708

A0A1E3Q4S7

0.485

A0A1E3QDJ7

0.485

A0A1E3QF11

0.485

A0A1E3Q5X8

0.418

A0A1E3PZQ5

0.406

Your Current Organism:

Lipomyces starkeyi

NCBI taxonomy Id: 675824
Other names: L. starkeyi NRRL Y-11557, Lipomyces starkeyi NRRL Y-11557

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1E3PZQ5	A0A1E3Q7Z0	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.769
A0A1E3PZQ5	A0A1E3Q9V3	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.881
A0A1E3PZQ5	A0A1E3QG03	3-hydroxy-3-methylglutaryl coenzyme A reductase.	BHLH domain-containing protein.	0.736
A0A1E3PZQ5	A0A1E3QGG3	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.406
A0A1E3Q4S7	A0A1E3QGG3	Uncharacterized protein; Belongs to the OSBP family.	Uncharacterized protein.	0.485
A0A1E3Q5X8	A0A1E3QG03	P/Homo B domain-containing protein.	BHLH domain-containing protein.	0.600
A0A1E3Q5X8	A0A1E3QGG3	P/Homo B domain-containing protein.	Uncharacterized protein.	0.418
A0A1E3Q7Z0	A0A1E3PZQ5	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.769
A0A1E3Q7Z0	A0A1E3QG03	Uncharacterized protein.	BHLH domain-containing protein.	0.472
A0A1E3Q7Z0	A0A1E3QGG3	Uncharacterized protein.	Uncharacterized protein.	0.708
A0A1E3Q9V3	A0A1E3PZQ5	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.881
A0A1E3Q9V3	A0A1E3QG03	Uncharacterized protein.	BHLH domain-containing protein.	0.630
A0A1E3Q9V3	A0A1E3QGG3	Uncharacterized protein.	Uncharacterized protein.	0.938
A0A1E3QDJ7	A0A1E3QGG3	Uncharacterized protein; Belongs to the OSBP family.	Uncharacterized protein.	0.485
A0A1E3QF11	A0A1E3QGG3	Uncharacterized protein.	Uncharacterized protein.	0.485
A0A1E3QG03	A0A1E3PZQ5	BHLH domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.736
A0A1E3QG03	A0A1E3Q5X8	BHLH domain-containing protein.	P/Homo B domain-containing protein.	0.600
A0A1E3QG03	A0A1E3Q7Z0	BHLH domain-containing protein.	Uncharacterized protein.	0.472
A0A1E3QG03	A0A1E3Q9V3	BHLH domain-containing protein.	Uncharacterized protein.	0.630
A0A1E3QG03	A0A1E3QGG3	BHLH domain-containing protein.	Uncharacterized protein.	0.988

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.806

expected number of edges:

28

PPI enrichment p-value:

0.0016

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1904059

Regulation of locomotor rhythm

3 of 15

2.69

1.97

0.00024

GO:0060158

Phospholipase C-activating dopamine receptor signaling pathway

2 of 2

3.39

1.59

0.0014

GO:0036151

Phosphatidylcholine acyl-chain remodeling

2 of 2

3.39

1.59

0.0014

GO:0034478

Phosphatidylglycerol catabolic process

2 of 2

3.39

1.59

0.0014

GO:0006640

Monoacylglycerol biosynthetic process

2 of 2

3.39

1.59

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

6 of 243

1.78

2.61

5.32e-07

GO:0019001

Guanyl nucleotide binding

6 of 305

1.68

2.38

1.01e-06

GO:0102545

Phosphatidyl phospholipase B activity

2 of 4

3.09

1.79

0.00059

GO:1902387

Ceramide 1-phosphate binding

2 of 5

2.99

1.73

0.00073

GO:0047499

Calcium-independent phospholipase A2 activity

2 of 5

2.99

1.73

0.00073

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044291

Cell-cell contact zone

2 of 8

2.79

1.17

0.0075

GO:0005834

Heterotrimeric G-protein complex

2 of 12

2.61

1.17

0.0075

GO:0005938

Cell cortex

3 of 276

1.43

0.68

0.0373

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2686

Mixed, incl. G alpha (12/13) signalling events, and Ephrin signaling

5 of 106

2.06

2.77

1.66e-06

CL:22874

Mixed, incl. Phosphatidyl phospholipase B activity, and MAP kinase activity

3 of 11

2.83

2.55

2.08e-05

CL:2827

NRAGE signals death through JNK, and G-protein activation

3 of 18

2.61

2.33

4.89e-05

CL:22876

phospho-PLA2 pathway, and MAP kinase activity

2 of 5

2.99

1.64

0.0011

CL:29771

Mixed, incl. Phosphatidylethanolamine binding, and RhoGEF domain

2 of 11

2.65

1.33

0.0037

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00591

Linoleic acid metabolism

2 of 27

2.26

1.19

0.0060

map00592

alpha-Linolenic acid metabolism

2 of 35

2.15

1.18

0.0060

map04310

Wnt signaling pathway

3 of 165

1.65

1.07

0.0060

map04020

Calcium signaling pathway

2 of 54

1.96

1.06

0.0091

map00565

Ether lipid metabolism

2 of 89

1.74

0.91

0.0160

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-418592

ADP signalling through P2Y purinoceptor 1

4 of 7

3.15

4.73

2.28e-09

MAP-392518

Signal amplification

4 of 14

2.85

4.2

1.58e-08

MAP-388396

GPCR downstream signalling

8 of 404

1.69

3.17

6.04e-10

MAP-372790

Signaling by GPCR

8 of 440

1.65

3.07

6.04e-10

MAP-112043

PLC beta mediated events

4 of 60

2.21

2.87

1.86e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044291

Cell-cell contact zone

2 of 7

2.85

1.16

0.0079

GOCC:0005834

Heterotrimeric G-protein complex

2 of 9

2.74

1.16

0.0079

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

3 of 100

1.87

1.32

0.0023

KW-0442

Lipid degradation

2 of 19

2.41

1.29

0.0042

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01735

Lysophospholipase catalytic domain

2 of 2

3.39

1.57

0.0015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003578

Small GTPase Rho

4 of 14

2.85

3.62

2.08e-07

IPR005225

Small GTP-binding protein domain

4 of 91

2.03

1.97

0.00011

IPR001806

Small GTPase

4 of 96

2.01

1.96

0.00011

IPR002642

Lysophospholipase, catalytic domain

2 of 2

3.39

1.71

0.00083

IPR000654

G-protein alpha subunit, group Q

2 of 2

3.39

1.71

0.00083

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

4 of 11

2.95

4.32

1.10e-08

SM00275

G protein alpha subunit

2 of 9

2.74

1.45

0.0023

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