SDD19426.1 protein (Auraticoccus monumenti) - STRING interaction network

Nodes:

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

SDD19426.1

Amino acid ABC transporter membrane protein, PAAT family. (218 aa)

Predicted Functional Partners:

SDD19469.1

0.998

SDD19389.1

0.995

SDE40110.1

0.980

SDE68727.1

0.980

SDE18711.1

0.979

SDE18781.1

0.973

SDE40150.1

0.889

SDE68643.1

0.877

SDE14663.1

0.801

SDE40257.1

0.590

Your Current Organism:

Auraticoccus monumenti

NCBI taxonomy Id: 675864
Other names: A. monumenti, Auraticoccus monumenti Alonso-Vega et al. 2011, CECT 7672, DSM 23257, LMG 25551, LMG:25551, Propionibacteriaceae bacterium MON 2.2, strain MON 2.2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDD19389.1	SDD19426.1	SAMN04489747_0404	SAMN04489747_0405	Amino acid ABC transporter ATP-binding protein, PAAT family.	Amino acid ABC transporter membrane protein, PAAT family.	0.995
SDD19389.1	SDD19469.1	SAMN04489747_0404	SAMN04489747_0406	Amino acid ABC transporter ATP-binding protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family.	0.985
SDD19389.1	SDE14663.1	SAMN04489747_0404	SAMN04489747_2631	Amino acid ABC transporter ATP-binding protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family; Belongs to the bacterial solute-binding protein 3 family.	0.847
SDD19389.1	SDE18781.1	SAMN04489747_0404	SAMN04489747_2743	Amino acid ABC transporter ATP-binding protein, PAAT family.	Polar amino acid transport system substrate-binding protein.	0.810
SDD19389.1	SDE40150.1	SAMN04489747_0404	SAMN04489747_3308	Amino acid ABC transporter ATP-binding protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family.	0.950
SDD19389.1	SDE40257.1	SAMN04489747_0404	SAMN04489747_3310	Amino acid ABC transporter ATP-binding protein, PAAT family.	Amino acid ABC transporter membrane protein 2, PAAT family.	0.984
SDD19389.1	SDE68643.1	SAMN04489747_0404	SAMN04489747_4085	Amino acid ABC transporter ATP-binding protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family.	0.866
SDD19426.1	SDD19389.1	SAMN04489747_0405	SAMN04489747_0404	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter ATP-binding protein, PAAT family.	0.995
SDD19426.1	SDD19469.1	SAMN04489747_0405	SAMN04489747_0406	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family.	0.998
SDD19426.1	SDE14663.1	SAMN04489747_0405	SAMN04489747_2631	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family; Belongs to the bacterial solute-binding protein 3 family.	0.801
SDD19426.1	SDE18711.1	SAMN04489747_0405	SAMN04489747_2741	Amino acid ABC transporter membrane protein, PAAT family.	Polar amino acid transport system ATP-binding protein.	0.979
SDD19426.1	SDE18781.1	SAMN04489747_0405	SAMN04489747_2743	Amino acid ABC transporter membrane protein, PAAT family.	Polar amino acid transport system substrate-binding protein.	0.973
SDD19426.1	SDE40110.1	SAMN04489747_0405	SAMN04489747_3307	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter ATP-binding protein, PAAT family.	0.980
SDD19426.1	SDE40150.1	SAMN04489747_0405	SAMN04489747_3308	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family.	0.889
SDD19426.1	SDE40257.1	SAMN04489747_0405	SAMN04489747_3310	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter membrane protein 2, PAAT family.	0.590
SDD19426.1	SDE68643.1	SAMN04489747_0405	SAMN04489747_4085	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family.	0.877
SDD19426.1	SDE68727.1	SAMN04489747_0405	SAMN04489747_4087	Amino acid ABC transporter membrane protein, PAAT family.	Amino acid ABC transporter ATP-binding protein, PAAT family.	0.980
SDD19469.1	SDD19389.1	SAMN04489747_0406	SAMN04489747_0404	Amino acid ABC transporter substrate-binding protein, PAAT family.	Amino acid ABC transporter ATP-binding protein, PAAT family.	0.985
SDD19469.1	SDD19426.1	SAMN04489747_0406	SAMN04489747_0405	Amino acid ABC transporter substrate-binding protein, PAAT family.	Amino acid ABC transporter membrane protein, PAAT family.	0.998
SDD19469.1	SDE14663.1	SAMN04489747_0406	SAMN04489747_2631	Amino acid ABC transporter substrate-binding protein, PAAT family.	Amino acid ABC transporter substrate-binding protein, PAAT family; Belongs to the bacterial solute-binding protein 3 family.	0.714

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Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

11

PPI enrichment p-value:

0.071

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 9

2.85

2.37

4.71e-05

GO:0000819

Sister chromatid segregation

5 of 113

1.97

2.35

1.14e-05

GO:0000712

Resolution of meiotic recombination intermediates

3 of 17

2.57

2.12

0.00012

GO:0048524

Positive regulation of viral process

3 of 25

2.4

1.96

0.00021

GO:0045069

Regulation of viral genome replication

3 of 26

2.39

1.96

0.00021

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

3 of 5

3.1

2.71

1.19e-05

GO:0005080

Protein kinase C binding

3 of 32

2.3

1.77

0.00046

GO:0031208

POZ domain binding

2 of 3

3.15

1.58

0.0014

GO:0042826

Histone deacetylase binding

3 of 57

2.05

1.47

0.0014

GO:0030332

Cyclin binding

2 of 14

2.48

1.12

0.0087

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005827

Polar microtubule

2 of 5

2.93

1.25

0.0054

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35892871

(2022) High-Throughput CRISPR Screening in Hematological Neoplasms.

3 of 117

1.73

1.04

0.0079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2630

Mixed, incl. Protein sumoylation, and DNA topological change

4 of 38

2.35

2.51

1.53e-05

CL:8237

Stem cell division, and SPOP, C-terminal BACK domain

2 of 5

2.93

1.19

0.0072

CL:2689

DNA topological change, and tyrosyl-DNA phosphodiesterase activity

2 of 7

2.78

1.12

0.0093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdu04120

Ubiquitin mediated proteolysis

3 of 150

1.63

1.02

0.0074

sdu04340

Hedgehog signaling pathway

2 of 58

1.86

0.8

0.0294

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-4615885

SUMOylation of DNA replication proteins

3 of 56

2.05

1.24

0.0042

MAP-9706019

RHOBTB3 ATPase cycle

2 of 19

2.35

0.95

0.0177

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

5 of 569

1.27

0.93

0.0042

MAP-983169

Class I MHC mediated antigen processing & presentation

5 of 655

1.21

0.89

0.0042

MAP-9013418

RHOBTB2 GTPase cycle

2 of 31

2.13

0.78

0.0355

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009330

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

3 of 3

3.32

3.11

2.44e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001241

DNA topoisomerase, type IIA

3 of 3

3.32

2.73

1.18e-05

IPR013760

DNA topoisomerase, type IIA-like domain superfamily

2 of 2

3.32

1.3

0.0046

IPR013758

DNA topoisomerase, type IIA, domain A, alpha-beta

2 of 2

3.32

1.3

0.0046

IPR013757

DNA topoisomerase, type IIA, alpha-helical domain superfamily

2 of 2

3.32

1.3

0.0046

IPR002205

DNA topoisomerase, type IIA, domain A

2 of 2

3.32

1.3

0.0046

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00434

DNA Topoisomerase IV

2 of 2

3.32

1.67

0.00097

SM00433

TopoisomeraseII

2 of 2

3.32

1.67

0.00097

SM00884

Cullin protein neddylation domain

2 of 9

2.67

1.38

0.0030

SM00182

Cullin

2 of 9

2.67

1.38

0.0030

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