STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)    
Predicted Functional Partners:
sucD
Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
sucB
Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.998
sdhA
Unannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.995
sdhB
Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.995
frdB
Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.993
frdA
Unannotated protein.
 
 0.993
sucA
Unannotated protein.
 
 0.993
aceF
Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.992
sdhC
Unannotated protein.
  
 
 0.992
sdhD
Unannotated protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.992
Your Current Organism:
Vibrio fluvialis
NCBI taxonomy Id: 676
Other names: ATCC 33809, CAIM 593, CCUG 13622, CCUG 20252, CIP 103355, DSM 19283, JCM 3752, LMG 7894, LMG:7894, NBRC 103150, NCCB 81034, NCTC 11327, V. fluvialis, strain VL 5125
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