| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KMK51523.1 | KMK51823.1 | RO21_05835 | RO21_04640 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.476 |
| KMK51523.1 | KMK51999.1 | RO21_05835 | RO21_03415 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.476 |
| KMK51523.1 | KMK52171.1 | RO21_05835 | RO21_02350 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.655 |
| KMK51823.1 | KMK51523.1 | RO21_04640 | RO21_05835 | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.476 |
| KMK51823.1 | KMK51999.1 | RO21_04640 | RO21_03415 | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.475 |
| KMK51823.1 | KMK52171.1 | RO21_04640 | RO21_02350 | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.539 |
| KMK51999.1 | KMK51523.1 | RO21_03415 | RO21_05835 | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.476 |
| KMK51999.1 | KMK51823.1 | RO21_03415 | RO21_04640 | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.475 |
| KMK51999.1 | KMK52171.1 | RO21_03415 | RO21_02350 | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.520 |
| KMK51999.1 | argR | RO21_03415 | RO21_03410 | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Arginine repressor; Regulates arginine biosynthesis genes. | 0.794 |
| KMK51999.1 | mdh | RO21_03415 | RO21_03405 | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.533 |
| KMK51999.1 | raiA | RO21_03415 | RO21_08820 | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribosome-associated inhibitor A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.424 |
| KMK52171.1 | KMK51523.1 | RO21_02350 | RO21_05835 | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.655 |
| KMK52171.1 | KMK51823.1 | RO21_02350 | RO21_04640 | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.539 |
| KMK52171.1 | KMK51999.1 | RO21_02350 | RO21_03415 | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.520 |
| argR | KMK51999.1 | RO21_03410 | RO21_03415 | Arginine repressor; Regulates arginine biosynthesis genes. | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.794 |
| argR | mdh | RO21_03410 | RO21_03405 | Arginine repressor; Regulates arginine biosynthesis genes. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.782 |
| mdh | KMK51999.1 | RO21_03405 | RO21_03415 | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.533 |
| mdh | argR | RO21_03405 | RO21_03410 | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | Arginine repressor; Regulates arginine biosynthesis genes. | 0.782 |
| raiA | KMK51999.1 | RO21_08820 | RO21_03415 | Ribosome-associated inhibitor A; Derived by automated computational analysis using gene prediction method: Protein Homology. | Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.424 |