| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KMK50940.1 | KMK50943.1 | RO21_08960 | RO21_08975 | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | Dithiol-disulfide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.408 |
| KMK50940.1 | KMK50944.1 | RO21_08960 | RO21_08980 | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.408 |
| KMK50940.1 | ffh | RO21_08960 | RO21_05465 | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belo [...] | 0.465 |
| KMK50940.1 | rapA | RO21_08960 | RO21_09250 | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | ATP-dependent helicase; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.401 |
| KMK50940.1 | secY | RO21_08960 | RO21_08365 | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.511 |
| KMK50940.1 | xerC | RO21_08960 | RO21_08970 | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | Site-specific tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.408 |
| KMK50940.1 | yidC | RO21_08960 | RO21_08965 | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | Membrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.781 |
| KMK50943.1 | KMK50940.1 | RO21_08975 | RO21_08960 | Dithiol-disulfide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | 0.408 |
| KMK50943.1 | KMK50944.1 | RO21_08975 | RO21_08980 | Dithiol-disulfide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |
| KMK50943.1 | xerC | RO21_08975 | RO21_08970 | Dithiol-disulfide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Site-specific tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.773 |
| KMK50943.1 | yidC | RO21_08975 | RO21_08965 | Dithiol-disulfide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.503 |
| KMK50944.1 | KMK50940.1 | RO21_08980 | RO21_08960 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | 0.408 |
| KMK50944.1 | KMK50943.1 | RO21_08980 | RO21_08975 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dithiol-disulfide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |
| KMK50944.1 | xerC | RO21_08980 | RO21_08970 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Site-specific tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.773 |
| KMK50944.1 | yidC | RO21_08980 | RO21_08965 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Membrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.502 |
| ffh | KMK50940.1 | RO21_05465 | RO21_08960 | Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belo [...] | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | 0.465 |
| ffh | secY | RO21_05465 | RO21_08365 | Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belo [...] | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.870 |
| ffh | yidC | RO21_05465 | RO21_08965 | Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belo [...] | Membrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.694 |
| rapA | KMK50940.1 | RO21_09250 | RO21_08960 | ATP-dependent helicase; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | 0.401 |
| secY | KMK50940.1 | RO21_08365 | RO21_08960 | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | Preprotein translocase subunit SecA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. | 0.511 |