node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFA92155.1 | EFA92432.1 | HMPREF0650_1692 | HMPREF0650_2128 | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | 0.720 |
EFA92155.1 | EFA92483.1 | HMPREF0650_1692 | HMPREF0650_1230 | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | DnaJ domain protein; Identified by match to protein family HMM PF00226. | 0.522 |
EFA92155.1 | dnaJ | HMPREF0650_1692 | HMPREF0650_1103 | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.494 |
EFA92155.1 | dnaK | HMPREF0650_1692 | HMPREF0650_0963 | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.836 |
EFA92155.1 | groL | HMPREF0650_1692 | HMPREF0650_1131 | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.492 |
EFA92155.1 | rplP | HMPREF0650_1692 | HMPREF0650_2454 | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.402 |
EFA92432.1 | EFA92155.1 | HMPREF0650_2128 | HMPREF0650_1692 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | 0.720 |
EFA92432.1 | EFA92483.1 | HMPREF0650_2128 | HMPREF0650_1230 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | DnaJ domain protein; Identified by match to protein family HMM PF00226. | 0.960 |
EFA92432.1 | EFA92710.1 | HMPREF0650_2128 | HMPREF0650_2108 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.627 |
EFA92432.1 | clpB | HMPREF0650_2128 | HMPREF0650_0464 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.612 |
EFA92432.1 | dnaJ | HMPREF0650_2128 | HMPREF0650_1103 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.957 |
EFA92432.1 | dnaK | HMPREF0650_2128 | HMPREF0650_0963 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.993 |
EFA92432.1 | groL | HMPREF0650_2128 | HMPREF0650_1131 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.941 |
EFA92432.1 | groS | HMPREF0650_2128 | HMPREF0650_1132 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.799 |
EFA92432.1 | grpE | HMPREF0650_2128 | HMPREF0650_1102 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.676 |
EFA92483.1 | EFA92155.1 | HMPREF0650_1230 | HMPREF0650_1692 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Ankyrin repeat protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error; identified by match to protein family HMM PF00023. | 0.522 |
EFA92483.1 | EFA92432.1 | HMPREF0650_1230 | HMPREF0650_2128 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | 0.960 |
EFA92483.1 | EFA92710.1 | HMPREF0650_1230 | HMPREF0650_2108 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.730 |
EFA92483.1 | clpB | HMPREF0650_1230 | HMPREF0650_0464 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.730 |
EFA92483.1 | dnaK | HMPREF0650_1230 | HMPREF0650_0963 | DnaJ domain protein; Identified by match to protein family HMM PF00226. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.963 |