node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFA91834.1 | EFA91902.1 | HMPREF0650_1871 | HMPREF0650_1115 | MutS domain V protein; Identified by match to protein family HMM PF00488. | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | 0.556 |
EFA91834.1 | EFA92534.1 | HMPREF0650_1871 | HMPREF0650_1282 | MutS domain V protein; Identified by match to protein family HMM PF00488. | ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614. | 0.586 |
EFA91834.1 | dnaN | HMPREF0650_1871 | HMPREF0650_0426 | MutS domain V protein; Identified by match to protein family HMM PF00488. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.917 |
EFA91834.1 | mutL | HMPREF0650_1871 | HMPREF0650_1728 | MutS domain V protein; Identified by match to protein family HMM PF00488. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.977 |
EFA91834.1 | mutS | HMPREF0650_1871 | HMPREF0650_1930 | MutS domain V protein; Identified by match to protein family HMM PF00488. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.527 |
EFA91834.1 | mutS2 | HMPREF0650_1871 | HMPREF0650_0893 | MutS domain V protein; Identified by match to protein family HMM PF00488. | MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. | 0.611 |
EFA91834.1 | polA | HMPREF0650_1871 | HMPREF0650_0537 | MutS domain V protein; Identified by match to protein family HMM PF00488. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.918 |
EFA91834.1 | recA | HMPREF0650_1871 | HMPREF0650_1822 | MutS domain V protein; Identified by match to protein family HMM PF00488. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.485 |
EFA91834.1 | recQ | HMPREF0650_1871 | HMPREF0650_1735 | MutS domain V protein; Identified by match to protein family HMM PF00488. | ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM PF09382; match to protein family HMM TIGR00614; match to protein family HMM TIGR01389. | 0.586 |
EFA91834.1 | topA | HMPREF0650_1871 | HMPREF0650_2223 | MutS domain V protein; Identified by match to protein family HMM PF00488. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.554 |
EFA91902.1 | EFA91834.1 | HMPREF0650_1115 | HMPREF0650_1871 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | MutS domain V protein; Identified by match to protein family HMM PF00488. | 0.556 |
EFA91902.1 | EFA92534.1 | HMPREF0650_1115 | HMPREF0650_1282 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614. | 0.918 |
EFA91902.1 | dnaN | HMPREF0650_1115 | HMPREF0650_0426 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.995 |
EFA91902.1 | mutL | HMPREF0650_1115 | HMPREF0650_1728 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.838 |
EFA91902.1 | mutS | HMPREF0650_1115 | HMPREF0650_1930 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.407 |
EFA91902.1 | polA | HMPREF0650_1115 | HMPREF0650_0537 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.928 |
EFA91902.1 | recA | HMPREF0650_1115 | HMPREF0650_1822 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.903 |
EFA91902.1 | recQ | HMPREF0650_1115 | HMPREF0650_1735 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM PF09382; match to protein family HMM TIGR00614; match to protein family HMM TIGR01389. | 0.918 |
EFA91902.1 | topA | HMPREF0650_1115 | HMPREF0650_2223 | UvrD/REP helicase; Identified by match to protein family HMM PF00580; match to protein family HMM PF00929. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.657 |
EFA92534.1 | EFA91834.1 | HMPREF0650_1282 | HMPREF0650_1871 | ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614. | MutS domain V protein; Identified by match to protein family HMM PF00488. | 0.586 |