node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFC05550.1 | dnaA | HMPREF9013_1253 | HMPREF9013_1107 | Hypothetical protein. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.532 |
EFC05550.1 | dnaB | HMPREF9013_1253 | HMPREF9013_0889 | Hypothetical protein. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.894 |
EFC05561.1 | dnaB | HMPREF9013_1264 | HMPREF9013_0889 | UvrD/REP helicase; Identified by match to protein family HMM PF00580. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.828 |
EFC05561.1 | dnaG | HMPREF9013_1264 | HMPREF9013_0511 | UvrD/REP helicase; Identified by match to protein family HMM PF00580. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.601 |
EFC05784.1 | dnaA | HMPREF9013_0709 | HMPREF9013_1107 | Primosomal protein DnaI. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.532 |
EFC05784.1 | dnaB | HMPREF9013_0709 | HMPREF9013_0889 | Primosomal protein DnaI. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.894 |
EFC06185.1 | EFC06189.1 | HMPREF9013_0887 | HMPREF9013_0891 | Metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | 0.815 |
EFC06185.1 | dnaB | HMPREF9013_0887 | HMPREF9013_0889 | Metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.815 |
EFC06185.1 | rplI | HMPREF9013_0887 | HMPREF9013_0890 | Metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. | Ribosomal protein L9; Binds to the 23S rRNA. | 0.816 |
EFC06189.1 | EFC06185.1 | HMPREF9013_0891 | HMPREF9013_0887 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. | 0.815 |
EFC06189.1 | dnaB | HMPREF9013_0891 | HMPREF9013_0889 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.837 |
EFC06189.1 | rplI | HMPREF9013_0891 | HMPREF9013_0890 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Ribosomal protein L9; Binds to the 23S rRNA. | 0.848 |
EFC06374.1 | dnaB | HMPREF9013_1082 | HMPREF9013_0889 | DNA polymerase III, delta' subunit. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.801 |
EFC06374.1 | dnaX | HMPREF9013_1082 | HMPREF9013_1118 | DNA polymerase III, delta' subunit. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.935 |
dnaA | EFC05550.1 | HMPREF9013_1107 | HMPREF9013_1253 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Hypothetical protein. | 0.532 |
dnaA | EFC05784.1 | HMPREF9013_1107 | HMPREF9013_0709 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Primosomal protein DnaI. | 0.532 |
dnaA | dnaB | HMPREF9013_1107 | HMPREF9013_0889 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.934 |
dnaA | dnaG | HMPREF9013_1107 | HMPREF9013_0511 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.528 |
dnaA | dnaX | HMPREF9013_1107 | HMPREF9013_1118 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.579 |
dnaB | EFC05550.1 | HMPREF9013_0889 | HMPREF9013_1253 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | Hypothetical protein. | 0.894 |