node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFC05129.1 | EFC05881.1 | HMPREF9013_0407 | HMPREF9013_0076 | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.470 |
EFC05129.1 | adk | HMPREF9013_0407 | HMPREF9013_0908 | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.587 |
EFC05129.1 | apt | HMPREF9013_0407 | HMPREF9013_0590 | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.892 |
EFC05129.1 | guaA | HMPREF9013_0407 | HMPREF9013_1351 | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.998 |
EFC05129.1 | hpt | HMPREF9013_0407 | HMPREF9013_1433 | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.923 |
EFC05129.1 | tilS | HMPREF9013_0407 | HMPREF9013_1434 | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. | 0.833 |
EFC05129.1 | xpt | HMPREF9013_0407 | HMPREF9013_0984 | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.949 |
EFC05339.1 | adk | HMPREF9013_1364 | HMPREF9013_0908 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.613 |
EFC05339.1 | apt | HMPREF9013_1364 | HMPREF9013_0590 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.958 |
EFC05339.1 | deoD | HMPREF9013_1364 | HMPREF9013_0160 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | 0.948 |
EFC05339.1 | guaA | HMPREF9013_1364 | HMPREF9013_1351 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.680 |
EFC05339.1 | hpt | HMPREF9013_1364 | HMPREF9013_1433 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.966 |
EFC05339.1 | tilS | HMPREF9013_1364 | HMPREF9013_1434 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. | 0.554 |
EFC05339.1 | xpt | HMPREF9013_1364 | HMPREF9013_0984 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.958 |
EFC05881.1 | EFC05129.1 | HMPREF9013_0076 | HMPREF9013_0407 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571. | 0.470 |
EFC05881.1 | adk | HMPREF9013_0076 | HMPREF9013_0908 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.949 |
EFC05881.1 | apt | HMPREF9013_0076 | HMPREF9013_0590 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.409 |
EFC05881.1 | deoD | HMPREF9013_0076 | HMPREF9013_0160 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | 0.465 |
EFC05881.1 | guaA | HMPREF9013_0076 | HMPREF9013_1351 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.752 |
EFC05881.1 | hflB-2 | HMPREF9013_0076 | HMPREF9013_1432 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.437 |