STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EHI56671.1Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (205 aa)    
Predicted Functional Partners:
EHI56670.1
Hypothetical protein.
 
  
 0.993
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
 
 0.960
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
 
  0.937
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.929
EHI56698.1
Hypothetical protein.
 
    0.891
EHI56403.1
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 
 0.888
EHI56673.1
Hypothetical protein.
  
    0.853
EHI56672.1
Hypothetical protein.
       0.754
EHI56609.1
Hypothetical protein; Belongs to the Nudix hydrolase family.
  
 
 0.734
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.729
Your Current Organism:
Johnsonella ignava
NCBI taxonomy Id: 679200
Other names: J. ignava ATCC 51276, Johnsonella ignava ATCC 51276, Johnsonella ignava str. ATCC 51276, Johnsonella ignava strain ATCC 51276
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