EHI56690.1 protein (Johnsonella ignava) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

EHI56690.1

Hypothetical protein. (204 aa)

Predicted Functional Partners:

EHI56689.1

0.894

EHI56688.1

0.869

EHI54633.1

0.585

EHI55779.1

0.519

EHI55780.1

0.517

EHI55666.1

0.501

EHI55667.1

0.490

EHI56691.1

0.465

EHI54654.1

0.434

EHI54642.1

0.427

Your Current Organism:

Johnsonella ignava

NCBI taxonomy Id: 679200
Other names: J. ignava ATCC 51276, Johnsonella ignava ATCC 51276, Johnsonella ignava str. ATCC 51276, Johnsonella ignava strain ATCC 51276

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHI54633.1	EHI54654.1	HMPREF9333_02186	HMPREF9333_02182	Hypothetical protein.	Hypothetical protein.	0.775
EHI54633.1	EHI55666.1	HMPREF9333_02186	HMPREF9333_01381	Hypothetical protein.	Hypothetical protein.	0.427
EHI54633.1	EHI55779.1	HMPREF9333_02186	HMPREF9333_01126	Hypothetical protein.	Hypothetical protein.	0.425
EHI54633.1	EHI56688.1	HMPREF9333_02186	HMPREF9333_00135	Hypothetical protein.	Hypothetical protein.	0.415
EHI54633.1	EHI56690.1	HMPREF9333_02186	HMPREF9333_00137	Hypothetical protein.	Hypothetical protein.	0.585
EHI54642.1	EHI56690.1	HMPREF9333_02195	HMPREF9333_00137	Hypothetical protein.	Hypothetical protein.	0.427
EHI54654.1	EHI54633.1	HMPREF9333_02182	HMPREF9333_02186	Hypothetical protein.	Hypothetical protein.	0.775
EHI54654.1	EHI56690.1	HMPREF9333_02182	HMPREF9333_00137	Hypothetical protein.	Hypothetical protein.	0.434
EHI55666.1	EHI54633.1	HMPREF9333_01381	HMPREF9333_02186	Hypothetical protein.	Hypothetical protein.	0.427
EHI55666.1	EHI55667.1	HMPREF9333_01381	HMPREF9333_01382	Hypothetical protein.	Hypothetical protein.	0.818
EHI55666.1	EHI56690.1	HMPREF9333_01381	HMPREF9333_00137	Hypothetical protein.	Hypothetical protein.	0.501
EHI55667.1	EHI55666.1	HMPREF9333_01382	HMPREF9333_01381	Hypothetical protein.	Hypothetical protein.	0.818
EHI55667.1	EHI56690.1	HMPREF9333_01382	HMPREF9333_00137	Hypothetical protein.	Hypothetical protein.	0.490
EHI55779.1	EHI54633.1	HMPREF9333_01126	HMPREF9333_02186	Hypothetical protein.	Hypothetical protein.	0.425
EHI55779.1	EHI55780.1	HMPREF9333_01126	HMPREF9333_01127	Hypothetical protein.	Hypothetical protein.	0.818
EHI55779.1	EHI56690.1	HMPREF9333_01126	HMPREF9333_00137	Hypothetical protein.	Hypothetical protein.	0.519
EHI55780.1	EHI55779.1	HMPREF9333_01127	HMPREF9333_01126	Hypothetical protein.	Hypothetical protein.	0.818
EHI55780.1	EHI56690.1	HMPREF9333_01127	HMPREF9333_00137	Hypothetical protein.	Hypothetical protein.	0.517
EHI56688.1	EHI54633.1	HMPREF9333_00135	HMPREF9333_02186	Hypothetical protein.	Hypothetical protein.	0.415
EHI56688.1	EHI56689.1	HMPREF9333_00135	HMPREF9333_00136	Hypothetical protein.	Hypothetical protein.	0.823

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.809

expected number of edges:

22

PPI enrichment p-value:

0.00834

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010467

Gene expression

10 of 175

1.05

1.27

1.82e-07

GO:0006351

Transcription, DNA-templated

4 of 27

1.46

1.14

0.0022

GO:0016070

RNA metabolic process

7 of 108

1.1

9.95e-05

GO:0006353

DNA-templated transcription, termination

2 of 4

1.99

0.81

0.0292

GO:0009059

Macromolecule biosynthetic process

7 of 187

0.87

0.68

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 85

1.21

1.36

1.59e-05

GO:0003676

Nucleic acid binding

10 of 298

0.82

0.79

1.59e-05

GO:0003899

DNA-directed 5-3 RNA polymerase activity

2 of 5

1.89

0.77

0.0339

GO:0140098

Catalytic activity, acting on RNA

4 of 70

1.05

0.58

0.0321

GO:0140640

Catalytic activity, acting on a nucleic acid

5 of 138

0.85

0.49

0.0321

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:412

RNA degradation, and 3-5-exoribonuclease activity

3 of 6

1.99

1.67

0.00048

CL:53

Mixed, incl. Gene expression, and Nucleoside triphosphate biosynthetic process

10 of 187

1.02

1.21

1.60e-07

CL:62

Ribosomal protein, and Ribonucleoside triphosphate biosynthetic process

7 of 103

1.12

1.19

3.40e-05

CL:246

RNA polymerase

2 of 5

1.89

0.84

0.0247

CL:227

Mixed, incl. Ribosomal small subunit biogenesis, and PUA domain superfamily

2 of 7

1.75

0.73

0.0383

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ace03018

RNA degradation

4 of 10

1.89

2.09

3.58e-05

ace03020

RNA polymerase

2 of 4

1.99

0.92

0.0177

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

6 of 63

1.27

1.34

6.85e-05

KW-0806

Transcription termination

2 of 3

2.12

0.88

0.0233

KW-0240

DNA-directed RNA polymerase

2 of 5

1.89

0.78

0.0325

KW-0548

Nucleotidyltransferase

3 of 34

1.24

0.65

0.0325

KW-0804

Transcription

4 of 78

1.0

0.56

0.0325

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003029

S1 domain

3 of 4

2.17

1.29

0.0037

IPR022967

RNA-binding domain, S1

3 of 5

2.07

1.27

0.0037

IPR012340

Nucleic acid-binding, OB-fold

4 of 29

1.43

1.0

0.0050

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00316

Ribosomal protein S1-like RNA-binding domain

3 of 5

2.07

1.67

0.00054

SM00322

K homology RNA-binding domain

2 of 5

1.89

0.84

0.0245

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