EHI55848.1 protein (Johnsonella ignava) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EHI55848.1

Hypothetical protein. (210 aa)

Predicted Functional Partners:

ecfA

0.752

ecfA-2

0.716

EHI56023.1

0.716

EHI55491.1

0.687

EHI56646.1

0.647

EHI56022.1

0.647

EHI55506.1

0.647

EHI55664.1

0.647

EHI54741.1

0.647

EHI54644.1

0.647

Your Current Organism:

Johnsonella ignava

NCBI taxonomy Id: 679200
Other names: J. ignava ATCC 51276, Johnsonella ignava ATCC 51276, Johnsonella ignava str. ATCC 51276, Johnsonella ignava strain ATCC 51276

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHI54644.1	EHI55491.1	HMPREF9333_02197	HMPREF9333_01206	Hypothetical protein.	Hypothetical protein.	0.724
EHI54644.1	EHI55848.1	HMPREF9333_02197	HMPREF9333_00891	Hypothetical protein.	Hypothetical protein.	0.647
EHI54644.1	EHI56023.1	HMPREF9333_02197	HMPREF9333_00805	Hypothetical protein.	Hypothetical protein.	0.742
EHI54644.1	ecfA	HMPREF9333_02197	HMPREF9333_00094	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.742
EHI54644.1	ecfA-2	HMPREF9333_02197	HMPREF9333_00095	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.742
EHI54741.1	EHI55848.1	HMPREF9333_02104	HMPREF9333_00891	Hypothetical protein.	Hypothetical protein.	0.647
EHI54741.1	EHI56023.1	HMPREF9333_02104	HMPREF9333_00805	Hypothetical protein.	Hypothetical protein.	0.780
EHI54741.1	ecfA	HMPREF9333_02104	HMPREF9333_00094	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.780
EHI54741.1	ecfA-2	HMPREF9333_02104	HMPREF9333_00095	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.780
EHI55491.1	EHI54644.1	HMPREF9333_01206	HMPREF9333_02197	Hypothetical protein.	Hypothetical protein.	0.724
EHI55491.1	EHI55664.1	HMPREF9333_01206	HMPREF9333_01379	Hypothetical protein.	Hypothetical protein.	0.745
EHI55491.1	EHI55848.1	HMPREF9333_01206	HMPREF9333_00891	Hypothetical protein.	Hypothetical protein.	0.687
EHI55491.1	EHI56023.1	HMPREF9333_01206	HMPREF9333_00805	Hypothetical protein.	Hypothetical protein.	0.742
EHI55491.1	ecfA	HMPREF9333_01206	HMPREF9333_00094	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.742
EHI55491.1	ecfA-2	HMPREF9333_01206	HMPREF9333_00095	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.742
EHI55506.1	EHI55848.1	HMPREF9333_01221	HMPREF9333_00891	Hypothetical protein.	Hypothetical protein.	0.647
EHI55506.1	EHI56023.1	HMPREF9333_01221	HMPREF9333_00805	Hypothetical protein.	Hypothetical protein.	0.733
EHI55506.1	ecfA	HMPREF9333_01221	HMPREF9333_00094	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.733
EHI55506.1	ecfA-2	HMPREF9333_01221	HMPREF9333_00095	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.733
EHI55664.1	EHI55491.1	HMPREF9333_01379	HMPREF9333_01206	Hypothetical protein.	Hypothetical protein.	0.745

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.931

expected number of edges:

12

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071941

Nitrogen cycle metabolic process

3 of 13

1.85

0.91

0.0177

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051536

Iron-sulfur cluster binding

5 of 70

1.34

1.13

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2489

Multiheme cytochrome superfamily, and Nitrate assimilation

5 of 5

2.49

4.1

1.10e-08

CL:2462

Mixed, incl. Electron transport, and Immunoglobulin-like fold

6 of 19

1.99

3.51

1.10e-08

CL:2362

Mixed, incl. Oxidative phosphorylation, and Heme binding

8 of 69

1.55

2.63

5.34e-09

CL:2852

Mixed, incl. BFD-like [2Fe-2S]-binding domain, and Alkanesulfonate transport

3 of 6

2.19

1.87

0.00025

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

3 of 31

1.48

0.81

0.0184

map01120

Microbial metabolism in diverse environments

6 of 341

0.74

0.47

0.0204

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

3 of 15

1.79

1.31

0.0021

KW-0534

Nitrate assimilation

2 of 2

2.49

1.31

0.0040

KW-0408

Iron

5 of 68

1.36

1.29

0.00034

KW-0574

Periplasm

2 of 7

1.95

1.04

0.0101

KW-0500

Molybdenum

2 of 7

1.95

1.04

0.0101

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01568

Molydopterin dinucleotide binding domain

2 of 2

2.49

0.84

0.0298

PF04324

BFD-like [2Fe-2S] binding domain

2 of 3

2.31

0.83

0.0298

PF00384

Molybdopterin oxidoreductase

2 of 3

2.31

0.83

0.0298

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00926

Molybdopterin oxidoreductase Fe4S4 domain

2 of 2

2.49

1.23

0.0055

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