EHI54886.1 protein (Johnsonella ignava) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EHI54886.1

Hypothetical protein. (73 aa)

Predicted Functional Partners:

EHI54885.1

0.790

EHI54883.1

0.776

EHI54884.1

0.773

Your Current Organism:

Johnsonella ignava

NCBI taxonomy Id: 679200
Other names: J. ignava ATCC 51276, Johnsonella ignava ATCC 51276, Johnsonella ignava str. ATCC 51276, Johnsonella ignava strain ATCC 51276

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHI54883.1	EHI54884.1	HMPREF9333_01895	HMPREF9333_01896	Hypothetical protein.	Hypothetical protein.	0.908
EHI54883.1	EHI54885.1	HMPREF9333_01895	HMPREF9333_01897	Hypothetical protein.	Hypothetical protein.	0.946
EHI54883.1	EHI54886.1	HMPREF9333_01895	HMPREF9333_01898	Hypothetical protein.	Hypothetical protein.	0.776
EHI54884.1	EHI54883.1	HMPREF9333_01896	HMPREF9333_01895	Hypothetical protein.	Hypothetical protein.	0.908
EHI54884.1	EHI54885.1	HMPREF9333_01896	HMPREF9333_01897	Hypothetical protein.	Hypothetical protein.	0.980
EHI54884.1	EHI54886.1	HMPREF9333_01896	HMPREF9333_01898	Hypothetical protein.	Hypothetical protein.	0.773
EHI54885.1	EHI54883.1	HMPREF9333_01897	HMPREF9333_01895	Hypothetical protein.	Hypothetical protein.	0.946
EHI54885.1	EHI54884.1	HMPREF9333_01897	HMPREF9333_01896	Hypothetical protein.	Hypothetical protein.	0.980
EHI54885.1	EHI54886.1	HMPREF9333_01897	HMPREF9333_01898	Hypothetical protein.	Hypothetical protein.	0.790
EHI54886.1	EHI54883.1	HMPREF9333_01898	HMPREF9333_01895	Hypothetical protein.	Hypothetical protein.	0.776
EHI54886.1	EHI54884.1	HMPREF9333_01898	HMPREF9333_01896	Hypothetical protein.	Hypothetical protein.	0.773
EHI54886.1	EHI54885.1	HMPREF9333_01898	HMPREF9333_01897	Hypothetical protein.	Hypothetical protein.	0.790

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.872

expected number of edges:

10

PPI enrichment p-value:

0.00369

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000731

DNA synthesis involved in DNA repair

10 of 26

2.76

11.03

5.68e-23

GO:0019985

Translesion synthesis

8 of 19

2.8

8.78

7.61e-18

GO:0042276

Error-prone translesion synthesis

6 of 10

2.96

6.85

1.42e-13

GO:0006281

DNA repair

11 of 362

1.66

4.03

1.13e-15

GO:0006260

DNA replication

6 of 150

1.78

2.82

1.12e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003887

DNA-directed DNA polymerase activity

6 of 20

2.66

5.69

9.63e-12

GO:0016779

Nucleotidyltransferase activity

7 of 110

1.98

4.1

1.53e-10

GO:0140097

Catalytic activity, acting on DNA

8 of 215

1.75

3.5

1.31e-10

GO:0003684

Damaged DNA binding

4 of 48

2.1

2.46

1.05e-05

GO:0017125

Deoxycytidyl transferase activity

2 of 2

3.18

1.77

0.00064

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042575

DNA polymerase complex

5 of 15

2.7

4.77

8.93e-10

GO:0016035

Zeta DNA polymerase complex

4 of 5

3.08

4.4

8.64e-09

GO:0140535

Intracellular protein-containing complex

6 of 610

1.17

1.16

0.00015

GO:1990234

Transferase complex

6 of 663

1.14

1.09

0.00021

GO:0005694

Chromosome

6 of 774

1.07

0.97

0.00044

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34548904

(2021) Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and redprocessed meat carcinogens by modeling exposure in normal colon organoids.

3 of 18

2.4

1.44

0.0021

PMID:29928064

(2018) Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus.

2 of 5

2.78

0.84

0.0306

PMID:27783675

(2016) DNA Polymerase kappa Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus.

2 of 5

2.78

0.84

0.0306

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:524

Polymerase switching, and Error-prone translesion synthesis

9 of 24

2.75

9.79

2.93e-20

CL:299

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), and Activation of the pre-replicative complex

11 of 137

2.08

7.12

3.52e-20

CL:557

Zeta DNA polymerase complex

4 of 5

3.08

4.42

8.03e-09

CL:310

Flap endonuclease activity, and DNA recombinase assembly

2 of 7

2.64

1.17

0.0075

CL:525

Polymerase switching, and Epsilon DNA polymerase complex

2 of 16

2.28

0.87

0.0249

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla03460

Fanconi anemia pathway

5 of 39

2.29

3.98

7.78e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-110313

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

9 of 43

2.5

8.43

1.26e-18

MAP-73893

DNA Damage Bypass

9 of 51

2.43

8.07

2.53e-18

MAP-5656121

Translesion synthesis by POLI

6 of 22

2.61

5.93

2.47e-12

MAP-5655862

Translesion synthesis by POLK

6 of 22

2.61

5.93

2.47e-12

MAP-5656169

Termination of translesion DNA synthesis

6 of 33

2.44

5.36

1.42e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042575

DNA polymerase complex

5 of 16

2.67

4.66

1.37e-09

GOCC:0016035

Zeta DNA polymerase complex

3 of 3

3.18

3.07

2.72e-06

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

6 of 232

1.59

2.12

2.72e-06

GOCC:0031981

Nuclear lumen

8 of 861

1.15

1.35

2.99e-06

GOCC:0005654

Nucleoplasm

5 of 507

1.17

0.96

0.0018

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

2 of 20

2.18

0.83

0.0287

KW-0235

DNA replication

2 of 25

2.08

0.83

0.0287

KW-0234

DNA repair

2 of 24

2.1

0.83

0.0287

KW-0238

DNA-binding

4 of 493

1.09

0.61

0.0287

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF11799

impB/mucB/samB family C-terminal domain

3 of 4

3.05

2.66

1.47e-05

PF00817

impB/mucB/samB family

3 of 4

3.05

2.66

1.47e-05

PF11798

IMS family HHH motif

2 of 2

3.18

1.57

0.0015

PF00136

DNA polymerase family B

2 of 2

3.18

1.57

0.0015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036775

DNA polymerase, Y-family, little finger domain superfamily

3 of 4

3.05

2.39

4.57e-05

IPR017961

DNA polymerase, Y-family, little finger domain

3 of 4

3.05

2.39

4.57e-05

IPR001126

UmuC domain

3 of 4

3.05

2.39

4.57e-05

IPR043128

Reverse transcriptase/Diguanylate cyclase domain

3 of 26

2.24

1.55

0.0012

IPR030559

DNA polymerase zeta catalytic subunit

2 of 2

3.18

1.45

0.0024

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About