EHI54786.1 protein (Johnsonella ignava) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

EHI54786.1

Hypothetical protein. (596 aa)

Predicted Functional Partners:

EHI54787.1

0.682

EHI54784.1

0.522

EHI54785.1

0.522

EHI54781.1

0.508

EHI54782.1

0.501

EHI54783.1

0.499

Your Current Organism:

Johnsonella ignava

NCBI taxonomy Id: 679200
Other names: J. ignava ATCC 51276, Johnsonella ignava ATCC 51276, Johnsonella ignava str. ATCC 51276, Johnsonella ignava strain ATCC 51276

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHI54781.1	EHI54782.1	HMPREF9333_02070	HMPREF9333_02071	Hypothetical protein.	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.995
EHI54781.1	EHI54783.1	HMPREF9333_02070	HMPREF9333_02072	Hypothetical protein.	Hypothetical protein.	0.993
EHI54781.1	EHI54784.1	HMPREF9333_02070	HMPREF9333_02073	Hypothetical protein.	Hypothetical protein.	0.776
EHI54781.1	EHI54785.1	HMPREF9333_02070	HMPREF9333_02074	Hypothetical protein.	Hypothetical protein.	0.797
EHI54781.1	EHI54786.1	HMPREF9333_02070	HMPREF9333_02075	Hypothetical protein.	Hypothetical protein.	0.508
EHI54781.1	EHI54787.1	HMPREF9333_02070	HMPREF9333_02076	Hypothetical protein.	Hypothetical protein.	0.447
EHI54782.1	EHI54781.1	HMPREF9333_02071	HMPREF9333_02070	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.995
EHI54782.1	EHI54783.1	HMPREF9333_02071	HMPREF9333_02072	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.992
EHI54782.1	EHI54784.1	HMPREF9333_02071	HMPREF9333_02073	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.737
EHI54782.1	EHI54785.1	HMPREF9333_02071	HMPREF9333_02074	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.737
EHI54782.1	EHI54786.1	HMPREF9333_02071	HMPREF9333_02075	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.501
EHI54782.1	EHI54787.1	HMPREF9333_02071	HMPREF9333_02076	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.447
EHI54783.1	EHI54781.1	HMPREF9333_02072	HMPREF9333_02070	Hypothetical protein.	Hypothetical protein.	0.993
EHI54783.1	EHI54782.1	HMPREF9333_02072	HMPREF9333_02071	Hypothetical protein.	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.992
EHI54783.1	EHI54784.1	HMPREF9333_02072	HMPREF9333_02073	Hypothetical protein.	Hypothetical protein.	0.830
EHI54783.1	EHI54785.1	HMPREF9333_02072	HMPREF9333_02074	Hypothetical protein.	Hypothetical protein.	0.836
EHI54783.1	EHI54786.1	HMPREF9333_02072	HMPREF9333_02075	Hypothetical protein.	Hypothetical protein.	0.499
EHI54783.1	EHI54787.1	HMPREF9333_02072	HMPREF9333_02076	Hypothetical protein.	Hypothetical protein.	0.447
EHI54784.1	EHI54781.1	HMPREF9333_02073	HMPREF9333_02070	Hypothetical protein.	Hypothetical protein.	0.776
EHI54784.1	EHI54782.1	HMPREF9333_02073	HMPREF9333_02071	Hypothetical protein.	Hypothetical protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.737

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Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.836

expected number of edges:

11

PPI enrichment p-value:

3.37e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043122

Regulation of I-kappaB kinase/NF-kappaB signaling

8 of 123

2.14

5.23

9.49e-13

GO:0033209

Tumor necrosis factor-mediated signaling pathway

5 of 32

2.53

4.2

7.70e-09

GO:0071356

Cellular response to tumor necrosis factor

6 of 87

2.17

3.89

5.81e-09

GO:0019221

Cytokine-mediated signaling pathway

6 of 214

1.78

2.7

2.74e-07

GO:0046330

Positive regulation of JNK cascade

4 of 56

2.19

2.59

7.07e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005164

Tumor necrosis factor receptor binding

4 of 18

2.68

3.37

4.91e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33995423

(2021) Deciphering the Fine-Tuning of the Retinoic Acid-Inducible Gene-I Pathway in Teleost Fish and Beyond.

5 of 27

2.6

4.22

8.78e-09

PMID:22448234

(2012) Massively parallel RNA sequencing identifies a complex immune gene repertoire in the lophotrochozoan Mytilus edulis.

4 of 19

2.65

3.3

6.52e-07

PMID:31080451

(2019) Pattern Recognition by Melanoma Differentiation-Associated Gene 5 (Mda5) in Teleost Fish: A Review.

3 of 7

2.96

2.68

1.31e-05

PMID:18039395

(2007) Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish.

4 of 41

2.32

2.65

7.27e-06

PMID:22013926

(2011) A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.

3 of 9

2.85

2.58

1.92e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15151

Mixed, incl. Regulation of I-kappaB kinase/NF-kappaB signaling, and Toll-like receptor signaling pathway

9 of 136

2.15

6.09

2.66e-15

CL:15152

Mixed, incl. Toll-like receptor signaling pathway, and TNF signaling

8 of 114

2.18

5.58

1.66e-13

CL:15156

Toll-like receptor signaling pathway, and I-kappaB kinase/NF-kappaB signaling

6 of 49

2.42

4.98

9.30e-11

CL:15162

Mixed, incl. IRAK2 mediated activation of TAK1 complex, and Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

4 of 17

2.7

3.68

1.28e-07

CL:15186

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, and TIR domain

3 of 5

3.11

3.1

2.36e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04622

RIG-I-like receptor signaling pathway

6 of 60

2.33

5.07

2.87e-11

ola04621

NOD-like receptor signaling pathway

6 of 143

1.95

3.68

2.13e-09

ola05168

Herpes simplex virus 1 infection

6 of 211

1.79

3.08

1.38e-08

ola04620

Toll-like receptor signaling pathway

3 of 87

1.87

1.67

0.00036

ola04217

Necroptosis

3 of 137

1.67

1.37

0.0011

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-936964

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

5 of 9

3.08

5.75

2.51e-11

MAP-3270619

IRF3-mediated induction of type I IFN

3 of 5

3.11

3.26

1.16e-06

MAP-1834941

STING mediated induction of host immune responses

3 of 8

2.91

3.02

2.94e-06

MAP-3134975

Regulation of innate immune responses to cytosolic DNA

3 of 12

2.73

2.84

5.67e-06

MAP-937061

TRIF(TICAM1)-mediated TLR4 signaling

6 of 211

1.79

2.74

2.08e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035631

CD40 receptor complex

2 of 4

3.03

1.3

0.0046

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02176

TRAF-type zinc finger

3 of 8

2.91

2.49

2.84e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012227

TNF receptor-associated factor TRAF, metazoa

3 of 7

2.96

2.3

6.47e-05

IPR002083

MATH/TRAF domain

3 of 15

2.63

1.99

0.00022

IPR001293

Zinc finger, TRAF-type

3 of 19

2.53

1.92

0.00028

IPR008974

TRAF-like

3 of 24

2.43

1.83

0.00039

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00061

Meprin and TRAF homology

3 of 16

2.6

2.29

5.67e-05

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