STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serBPutative phosphoserine phosphatase; evidence=ISS; db_xref=cjejuni:Cj0282c; date=20070321; method=automatic:reciprocal fasta. (206 aa)    
Predicted Functional Partners:
hisI
Histidine biosynthesis bifunctional protein HisIE; evidence=ISS; db_xref=cdifficile:CD1554; date=20070321; method=automatic:reciprocal fasta; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.944
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.935
sdaA
L-serine deaminase 1; evidence=ISS; db_xref=smarcescens:SMA2084; date=20070321; method=automatic:reciprocal fasta; Belongs to the iron-sulfur dependent L-serine dehydratase family.
   
 
 0.913
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
   
 
 0.913
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
 0.910
pssA
CDP-diacylglycerol--serine O-phosphatidyltransferase; evidence=ISS; db_xref=cjejuni:Cj1114c; date=20070321; method=automatic:reciprocal fasta; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
    
  0.903
HMU01560
Putative Serine-pyruvate/aspartate aminotransferase class-V; evidence=ISS; db_xref=bparapertussis:BPP4201; date=20070321; method=automatic:reciprocal fasta.
   
 0.901
trpA
Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
  0.901
HMU01550
D-3-phosphoglycerate dehydrogenase; evidence=ISS; db_xref=saureusMSSA476:SAS1650; date=20070321; method=automatic:reciprocal fasta; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.854
hisF
Putative histidine biosynthesis protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.793
Your Current Organism:
Helicobacter mustelae
NCBI taxonomy Id: 679897
Other names: H. mustelae 12198, Helicobacter mustelae 12198, Helicobacter mustelae str. 12198, Helicobacter mustelae strain 12198
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.