STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; evidence=ISS; db_xref=bcenocepacia:CAL0317; date=20070321; method=automatic:reciprocal fasta. (273 aa)    
Predicted Functional Partners:
hisI
Histidine biosynthesis bifunctional protein HisIE; evidence=ISS; db_xref=cdifficile:CD1554; date=20070321; method=automatic:reciprocal fasta; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisF
Putative histidine biosynthesis protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.998
hisH
Putative imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 0.998
hisD
Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.977
hisB
Imidazoleglycerol-phosphate dehydratase; evidence=ISS; db_xref=cbotulinum:CBO1568; date=20070321; method=automatic:reciprocal fasta.
 
  
 0.976
hisG
Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.968
hisC
Probable histidinol-phosphate aminotransferase; evidence=ISS; db_xref=cjejuni:Cj0317; date=20070321; method=automatic:reciprocal fasta; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.926
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.766
serB
Putative phosphoserine phosphatase; evidence=ISS; db_xref=cjejuni:Cj0282c; date=20070321; method=automatic:reciprocal fasta.
  
  
 0.754
gmhB
D,D-heptose 1,7-bisphosphate phosphatase; evidence=ISS; db_xref=pmirabilis:PMI2258; date=20070321; method=automatic:reciprocal fasta.
  
  
 0.670
Your Current Organism:
Helicobacter mustelae
NCBI taxonomy Id: 679897
Other names: H. mustelae 12198, Helicobacter mustelae 12198, Helicobacter mustelae str. 12198, Helicobacter mustelae strain 12198
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.