Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HMU07130Putative radical SAM domain protein; evidence=ISS; db_xref=cjejuni:Cj1244; date=20070321; method=automatic:reciprocal fasta. (318 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
    0.818
obg
Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
 
 
    0.662
pcm
protein-L-isoaspartate O-methyltransferase; evidence=ISS; db_xref=cjejuni:Cj0228c; date=20070321; method=automatic:reciprocal fasta.
  
    0.629
flaB
Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
       0.585
HMU03550
Putative hypothetical protein; evidence=ISS.
 
     0.548
HMU07160
Putative hypothetical protein; Homologous to H. pylori HP0114 gene product involved in flagellar glycosylation.
       0.440
HMU07220
ABC transporter integral membrane protein; evidence=ISS; db_xref=cjejuni:Cj0141c; date=20070321; method=automatic:reciprocal fasta.
 
    0.426
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
    0.408
HMU07200
Putative ABC transporter ATP-binding protein; evidence=ISS; db_xref=cjejuni:Cj0142c; date=20070321; method=automatic:top fasta hit.
 
     0.406
HMU07190
Periplasmic solute binding protein for ABC transport system; evidence=ISS; db_xref=cjejuni:Cj0143c; date=20070321; method=automatic:reciprocal fasta.
 
    0.402
Your Current Organism:
Helicobacter mustelae
NCBI taxonomy Id: 679897
Other names: H. mustelae 12198, Helicobacter mustelae 12198, Helicobacter mustelae str. 12198, Helicobacter mustelae strain 12198
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