STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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hypFTranscriptional regulatory protein hypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (824 aa)    
Predicted Functional Partners:
hypE
Hydrogenase isoenzymes formation protein; evidence=ISS; db_xref=cjejuni:Cj0626; date=20070321; method=automatic:reciprocal fasta.
 
 
 0.971
hypD
Hydrogenase isoenzymes formation protein; evidence=ISS; db_xref=cjejuni:Cj0625; date=20070321; method=automatic:reciprocal fasta; Belongs to the HypD family.
 
  
 0.892
hypC
Hydrogenase isoenzymes formation protein; evidence=ISS; db_xref=cjejuni:Cj0624; date=20070321; method=automatic:reciprocal fasta.
 
 
 0.862
hypB
Putative periplasmic cytochrome C, partial gene (pseudogene); PS00190 Cytochrome c family heme-binding site signature.
 
   
 0.809
HMU07680
Putative deiminase; evidence=ISS; db_xref=bfragilisNCTC9343:BF2466; date=20070321; method=automatic:reciprocal fasta; Belongs to the agmatine deiminase family.
       0.759
tsaD
Putative glycoprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
       0.550
hypA
Hydrogenase expression /formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.544
hydB
Ni/Fe-hydrogenase large subunit; evidence=ISS; db_xref=cjejuni:Cj1266c; date=20070321; method=automatic:reciprocal fasta; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 
 0.539
hydD
Putative hydrogenase maturation protease; evidence=ISS; db_xref=cjejuni:Cj1264c; date=20070321; method=automatic:reciprocal fasta.
     
 0.463
ttdT
Putative tartrate transporter (tartrate/succinate antiporter); evidence=ISS; db_xref=eamylovora:AMY1538; date=20070321; method=automatic:reciprocal fasta.
       0.413
Your Current Organism:
Helicobacter mustelae
NCBI taxonomy Id: 679897
Other names: H. mustelae 12198, Helicobacter mustelae 12198, Helicobacter mustelae str. 12198, Helicobacter mustelae strain 12198
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.