node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alsS | edd | HMU11770 | HMU04950 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.674 |
alsS | ilvA | HMU11770 | HMU11800 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.981 |
alsS | ilvC | HMU11770 | HMU11790 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.997 |
alsS | ilvD | HMU11770 | HMU11760 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | Putative dihydroxy-acid dehydratase; evidence=ISS; db_xref=saureusMRSA252:SAR2140; date=20070321; method=automatic:reciprocal fasta; Belongs to the IlvD/Edd family. | 0.992 |
alsS | ilvH | HMU11770 | HMU11780 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | Acetolactate synthase small subunit; evidence=ISS; db_xref=ssuis:SSU1681; date=20070321; method=automatic:reciprocal fasta. | 0.999 |
alsS | leuA | HMU11770 | HMU10180 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.926 |
alsS | leuB | HMU11770 | HMU10170 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.962 |
alsS | leuC | HMU11770 | HMU10160 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.568 |
alsS | leuD | HMU11770 | HMU10150 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.648 |
alsS | purH | HMU11770 | HMU11830 | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; evidence=ISS; db_xref=cjejuni:Cj0953c; date=20070321; method=automatic:reciprocal fasta. | 0.609 |
edd | alsS | HMU04950 | HMU11770 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | 0.674 |
edd | ilvA | HMU04950 | HMU11800 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.662 |
edd | ilvC | HMU04950 | HMU11790 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.761 |
edd | ilvH | HMU04950 | HMU11780 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Acetolactate synthase small subunit; evidence=ISS; db_xref=ssuis:SSU1681; date=20070321; method=automatic:reciprocal fasta. | 0.573 |
edd | leuA | HMU04950 | HMU10180 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.735 |
edd | leuB | HMU04950 | HMU10170 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.760 |
edd | leuC | HMU04950 | HMU10160 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.776 |
edd | leuD | HMU04950 | HMU10150 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.634 |
ilvA | alsS | HMU11800 | HMU11770 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase large subunit; evidence=ISS; db_xref=ssuis:SSU1682; date=20070321; method=automatic:reciprocal fasta. | 0.981 |
ilvA | edd | HMU11800 | HMU04950 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.662 |