STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mpet_03317,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterProIPR007197:IPR006638:IPR005244:IPR019940:IPR 020050; KEGG: mem:Memar_0047 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: FO synthase subunit 2; TIGRFAM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; PFAM: Radical SAM superfamily; TIGRFAM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; radical SAM domain protein, CofH subfamily. (364 aa)    
Predicted Functional Partners:
cofG
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
0.994
cofH
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
  
  
 
0.903
Mpet_0332
InterPro IPR001733; KEGG: mpl:Mpal_0410 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: peptidase S26B, signal peptidase; TIGRFAM: signal peptidase I, archaeal type.
       0.899
Mpet_0323
COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: mbn:Mboo_0044 thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: Thiamine biosynthesis protein ThiC; TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC.
  
  
 0.757
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.754
Mpet_0953
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932:IPR011620:IPR010822; KEGG: mem:Memar_2468 stage II sporulation E family protein; PFAM: Stage II sporulation E family protein; 5TM Receptors of the LytS-YhcK type transmembrane region; SMART: protein phosphatase 2C domain protein; SPTR: Stage II sporulation E family protein; PFAM: 5TMR of 5TMR-LYT; Stage II sporulation protein E (SpoIIE).
  
  
 0.713
Mpet_0195
KEGG: apo:Arcpr_0028 thiamineS protein; SPTR: ThiamineS protein.
  
  
 0.711
Mpet_0954
Anti-sigma-factor antagonist; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR003658:IPR002645; KEGG: swo:Swol_1795 anti-anti-sigma regulatory factor, SpoIIAA; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Putative anti-sigma factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor.
  
    0.696
Mpet_0952
Putative anti-sigma regulatory factor, serine/threonine protein kinase; KEGG: dat:HRM2_41210 RsbW1; SPTR: RsbW1; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
    0.684
Mpet_0279
COGs: COG4032 thiamine-pyrophosphate-binding protein; InterPro IPR011766; KEGG: mem:Memar_0112 thiamine pyrophosphate binding domain-containing protein; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Sulfopyruvate decarboxylase subunit beta / sulfopyruvate decarboxylase subunit alpha; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
     
 0.621
Your Current Organism:
Methanolacinia petrolearia
NCBI taxonomy Id: 679926
Other names: M. petrolearia DSM 11571, Methanolacinia petrolearia DSM 11571, Methanoplanus petrolearius DSM 11571, Methanoplanus petrolearius SEBR 4847
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