Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Mpet_1995Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR007197; KEGG: mth:MTH1143 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; PFAM: Radical SAM superfamily. (351 aa)    
Predicted Functional Partners:
Mpet_2001
COGs: COG4018 conserved hypothetical protein; InterPro IPR016760; KEGG: mhu:Mhun_0231 hypothetical protein; PFAM: Uncharacterised conserved protein UCP019375; SPTR: Conserved protein (FlpA); PFAM: Fibrillarin-like archaeal protein.
  
  
 0.961
Mpet_1996
COGs: COG4019 conserved hypothetical protein; InterPro IPR012019; KEGG: mth:MTH1144 hypothetical protein; SPTR: Conserved protein; PFAM: Protein of unknown function (DUF3236).
     
 0.870
Mpet_1997
Protein of unknown function DUF1188; COGs: COG4017 conserved hypothetical protein; InterPro IPR009573; KEGG: mth:MTH1145 hypothetical protein; PFAM: Protein of unknown function DUF1188; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1188).
     
 0.870
Mpet_2000
Protein of unknown function UPF0254; COGs: COG4016 conserved hypothetical protein; InterPro IPR009625; KEGG: mla:Mlab_1743 hypothetical protein; PFAM: Protein of unknown function UPF0254; SPTR: UPF0254 protein Mlab_1743; PFAM: Uncharacterised protein family (UPF0254); Belongs to the UPF0254 family.
     
 0.826
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.818
Mpet_1999
Conserved hypothetical protein; COGs: COG4015 dinucleotide-utilizing protein of the ThiF/HesA family; InterPro IPR012028; KEGG: mth:MTH1147 hypothetical protein; SPTR: Conserved protein.
     
 0.812
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
  
 0.809
Mpet_1998
Protein of unknown function DUF34; COGs: COG0327 conserved hypothetical protein; InterPro IPR002678; KEGG: mhu:Mhun_0228 hypothetical protein; PFAM: protein of unknown function DUF34; SPTR: Putative uncharacterized protein; PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: conserved hypothetical protein TIGR00486.
 
     0.808
hmd
Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
  
  
 0.781
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
 
   
 0.739
Your Current Organism:
Methanolacinia petrolearia
NCBI taxonomy Id: 679926
Other names: M. petrolearia DSM 11571, Methanolacinia petrolearia DSM 11571, Methanoplanus petrolearius DSM 11571, Methanoplanus petrolearius SEBR 4847
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