STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hmdCoenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (342 aa)    
Predicted Functional Partners:
mtd
Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
     
 0.967
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family.
     
 0.951
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
  0.900
fae-hps
Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family.
     
  0.900
mer
5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
     
  0.900
Mpet_2001
COGs: COG4018 conserved hypothetical protein; InterPro IPR016760; KEGG: mhu:Mhun_0231 hypothetical protein; PFAM: Uncharacterised conserved protein UCP019375; SPTR: Conserved protein (FlpA); PFAM: Fibrillarin-like archaeal protein.
  
  
 0.859
Mpet_1995
Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR007197; KEGG: mth:MTH1143 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; PFAM: Radical SAM superfamily.
  
  
 0.781
Mpet_2718
COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501:IPR018194; KEGG: mem:Memar_1007 nickel-dependent hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: Nickel-dependent hydrogenase, large subunit; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
     
 0.562
Mpet_0590
COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501:IPR018194:IPR017682; KEGG: mhu:Mhun_2332 nickel-dependent hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: Coenzyme F420-reducing hydrogenase, alpha subunit; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; PFAM: Nickel-dependent hydrogenase; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
     
 0.541
Mpet_1996
COGs: COG4019 conserved hypothetical protein; InterPro IPR012019; KEGG: mth:MTH1144 hypothetical protein; SPTR: Conserved protein; PFAM: Protein of unknown function (DUF3236).
     
 0.507
Your Current Organism:
Methanolacinia petrolearia
NCBI taxonomy Id: 679926
Other names: M. petrolearia DSM 11571, Methanolacinia petrolearia DSM 11571, Methanoplanus petrolearius DSM 11571, Methanoplanus petrolearius SEBR 4847
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