Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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tgtAtRNA-guanine transglycosylase, various specificities; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (490 aa)    
Predicted Functional Partners:
Mpet_2092
PUA domain containing protein; COGs: COG1549 Queuine tRNA-ribosyltransferase contain PUA domain; InterPro IPR004521:IPR002478; KEGG: mem:Memar_1286 PUA domain-containing protein; PFAM: PUA domain containing protein; SMART: PUA domain containing protein; SPTR: PUA domain containing protein; PFAM: PUA domain; TIGRFAM: uncharacterized domain 2.
 
 
0.973
Mpet_0946
PUA domain containing protein; COGs: COG1370 Prefoldin molecular chaperone implicated in de novo protein folding alpha subunit; InterPro IPR004521:IPR002478; KEGG: mem:Memar_1685 PUA domain-containing protein; PFAM: PUA domain containing protein; SMART: PUA domain containing protein; SPTR: PUA domain containing protein; PFAM: PUA domain; TIGRFAM: uncharacterized domain 2.
     0.946
truB
Pseudouridylate synthase TruB domain protein; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
  
  
 0.769
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.754
Mpet_2094
COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006004:IPR013027:IPR000103:IPR002173; KEGG: mem:Memar_1282 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Sulfide dehydrogenase (Flavoprotein) subunit SudA; TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric.
     
 0.718
secD
SecD/SecF/SecDF export membrane protein; Involved in protein export.
 
  
 0.713
Mpet_2090
AMMECR1 domain protein; COGs: COG2078 conserved hypothetical protein; InterPro IPR002733; KEGG: mhu:Mhun_1122 AMMECR1; PFAM: AMMECR1 domain protein; SPTR: AMMECR1; PFAM: AMMECR1; TIGRFAM: conserved hypothetical protein TIGR00296.
 
     0.698
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
  
 0.685
Mpet_1355
Glycosyl transferase family 2; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR001732:IPR014026:IPR001173; KEGG: mpd:MCP_0949 hypothetical protein; PFAM: glycosyl transferase family 2; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; SPTR: Putative uncharacterized protein; manually curated; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; Glycosyl transferase family 2; TIGRFAM: nucleotide sugar dehydrogenase.
   
   0.670
Mpet_2093
Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterProIPR008333:IPR001433:IPR019480:IPR012165:IPR 017927; KEGG: mem:Memar_1283 ferredoxin-NADP(+) reductase subunit alpha; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; SPTR: Sulfide dehydrogenase (Flavoprotein) subunit SudB; PFAM: Iron-sulfur cluster bindin [...]
       0.662
Your Current Organism:
Methanolacinia petrolearia
NCBI taxonomy Id: 679926
Other names: M. petrolearia DSM 11571, Methanolacinia petrolearia DSM 11571, Methanoplanus petrolearius DSM 11571, Methanoplanus petrolearius SEBR 4847
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