STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mpet_2177KEGG: mpl:Mpal_0332 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Gar1/Naf1 RNA binding region. (77 aa)    
Predicted Functional Partners:
truB
Pseudouridylate synthase TruB domain protein; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
   
 0.999
nop10
RNA-binding protein Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
   
 0.999
rpl7ae
Ribosomal protein L7Ae/L30e/S12e/Gadd45; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
  
 0.997
Mpet_0393
Pre-mRNA processing ribonucleoprotein, binding domain protein; COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR002687; KEGG: mem:Memar_0541 pre-mRNA processing ribonucleoprotein, binding region; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; SPTR: rRNA biogenesis protein Nop56/Nop58; PFAM: Putative snoRNA binding domain.
  
 
 0.943
tfb
Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
  
  
 0.866
flpA
Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 
 0.813
Mpet_0665
DEAD/DEAH box helicase domain protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterProIPR014021:IPR001650:IPR014014:IPR011545:IPR 005580:IPR014001; KEGG: mla:Mlab_0371 hypothetical protein; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; DbpA RNA-binding domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; DbpA RNA binding domain; DEAD/DEAH box helicase.
  
 
 0.809
rps4
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
   0.732
guaAB
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.732
rps8e
COGs: COG2007 Ribosomal protein S8E; InterPro IPR001047; KEGG: mpl:Mpal_0336 ribosomal protein S8e; PFAM: Ribosomal protein S8E; SPTR: 30S ribosomal protein S8e; TIGRFAM: ribosomal protein S8e; PFAM: Ribosomal protein S8e; TIGRFAM: ribosomal protein S8.e.
  
    0.711
Your Current Organism:
Methanolacinia petrolearia
NCBI taxonomy Id: 679926
Other names: M. petrolearia DSM 11571, Methanolacinia petrolearia DSM 11571, Methanoplanus petrolearius DSM 11571, Methanoplanus petrolearius SEBR 4847
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