node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mpet_1731 | Mpet_2293 | Mpet_1731 | Mpet_2293 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR004039:IPR002932; KEGG: mmh:Mmah_1580 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; Rubredoxin-type Fe(Cys)4 protein; PRIAM: Glutamate synthase (NADPH); SPTR: Protein with rubredoxin and glutamine synthase domains; PFAM: Rubredoxin; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | 0.538 |
Mpet_1731 | Mpet_2295 | Mpet_1731 | Mpet_2295 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR004039:IPR002932; KEGG: mmh:Mmah_1580 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; Rubredoxin-type Fe(Cys)4 protein; PRIAM: Glutamate synthase (NADPH); SPTR: Protein with rubredoxin and glutamine synthase domains; PFAM: Rubredoxin; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. | COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006095:IPR006097:IPR006096:IPR014362; KEGG: mba:Mbar_A2938 glutamate dehydrogenase (NAD/NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: Glutamate dehydrogenase (NAD/NADP); PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.911 |
Mpet_1731 | aroE | Mpet_1731 | Mpet_2700 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR004039:IPR002932; KEGG: mmh:Mmah_1580 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; Rubredoxin-type Fe(Cys)4 protein; PRIAM: Glutamate synthase (NADPH); SPTR: Protein with rubredoxin and glutamine synthase domains; PFAM: Rubredoxin; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.532 |
Mpet_1731 | gatA | Mpet_1731 | Mpet_1932 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR004039:IPR002932; KEGG: mmh:Mmah_1580 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; Rubredoxin-type Fe(Cys)4 protein; PRIAM: Glutamate synthase (NADPH); SPTR: Protein with rubredoxin and glutamine synthase domains; PFAM: Rubredoxin; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). | 0.646 |
Mpet_1731 | nadE | Mpet_1731 | Mpet_1361 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR004039:IPR002932; KEGG: mmh:Mmah_1580 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; Rubredoxin-type Fe(Cys)4 protein; PRIAM: Glutamate synthase (NADPH); SPTR: Protein with rubredoxin and glutamine synthase domains; PFAM: Rubredoxin; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.583 |
Mpet_1731 | topA | Mpet_1731 | Mpet_1934 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR004039:IPR002932; KEGG: mmh:Mmah_1580 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; Rubredoxin-type Fe(Cys)4 protein; PRIAM: Glutamate synthase (NADPH); SPTR: Protein with rubredoxin and glutamine synthase domains; PFAM: Rubredoxin; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.533 |
Mpet_2292 | Mpet_2293 | Mpet_2292 | Mpet_2293 | Radical SAM domain protein; COGs: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); InterPro IPR013032:IPR007197:IPR017896:IPR006638; KEGG: mbn:Mboo_0580 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; PFAM: Radical SAM superfamily. | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | 0.584 |
Mpet_2292 | Mpet_2294 | Mpet_2292 | Mpet_2294 | Radical SAM domain protein; COGs: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); InterPro IPR013032:IPR007197:IPR017896:IPR006638; KEGG: mbn:Mboo_0580 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; PFAM: Radical SAM superfamily. | COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: mhu:Mhun_0284 cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: Cob(I)yrinic acid a,c-diamide adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | 0.451 |
Mpet_2292 | Mpet_2295 | Mpet_2292 | Mpet_2295 | Radical SAM domain protein; COGs: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); InterPro IPR013032:IPR007197:IPR017896:IPR006638; KEGG: mbn:Mboo_0580 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; PFAM: Radical SAM superfamily. | COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006095:IPR006097:IPR006096:IPR014362; KEGG: mba:Mbar_A2938 glutamate dehydrogenase (NAD/NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: Glutamate dehydrogenase (NAD/NADP); PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.405 |
Mpet_2293 | Mpet_1731 | Mpet_2293 | Mpet_1731 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR004039:IPR002932; KEGG: mmh:Mmah_1580 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; Rubredoxin-type Fe(Cys)4 protein; PRIAM: Glutamate synthase (NADPH); SPTR: Protein with rubredoxin and glutamine synthase domains; PFAM: Rubredoxin; Conserved region in glutamate synthase; Belongs to the glutamate synthase family. | 0.538 |
Mpet_2293 | Mpet_2292 | Mpet_2293 | Mpet_2292 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | Radical SAM domain protein; COGs: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); InterPro IPR013032:IPR007197:IPR017896:IPR006638; KEGG: mbn:Mboo_0580 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; PFAM: Radical SAM superfamily. | 0.584 |
Mpet_2293 | Mpet_2294 | Mpet_2293 | Mpet_2294 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: mhu:Mhun_0284 cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: Cob(I)yrinic acid a,c-diamide adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | 0.605 |
Mpet_2293 | Mpet_2295 | Mpet_2293 | Mpet_2295 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006095:IPR006097:IPR006096:IPR014362; KEGG: mba:Mbar_A2938 glutamate dehydrogenase (NAD/NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: Glutamate dehydrogenase (NAD/NADP); PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.622 |
Mpet_2293 | aroE | Mpet_2293 | Mpet_2700 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.685 |
Mpet_2293 | gatA | Mpet_2293 | Mpet_1932 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). | 0.594 |
Mpet_2293 | guaB | Mpet_2293 | Mpet_2358 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.787 |
Mpet_2293 | ileS | Mpet_2293 | Mpet_2134 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | 0.550 |
Mpet_2293 | nadE | Mpet_2293 | Mpet_1361 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.597 |
Mpet_2293 | topA | Mpet_2293 | Mpet_1934 | Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: cth:Cthe_0541 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.853 |
Mpet_2294 | Mpet_2292 | Mpet_2294 | Mpet_2292 | COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: mhu:Mhun_0284 cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: Cob(I)yrinic acid a,c-diamide adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | Radical SAM domain protein; COGs: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); InterPro IPR013032:IPR007197:IPR017896:IPR006638; KEGG: mbn:Mboo_0580 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; PFAM: Radical SAM superfamily. | 0.451 |