STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mpet_2581Adenosylhomocysteinase; COGs: COG0499 S-adenosylhomocysteine hydrolase; InterPro IPR000043:IPR015878:IPR020082; KEGG: mbn:Mboo_0660 S-adenosyl-L-homocysteine hydrolase; PFAM: S-adenosyl-L-homocysteine hydrolase, NAD binding; S-adenosyl-L-homocysteine hydrolase; PRIAM: Adenosylhomocysteinase; SPTR: Adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; manually curated; PFAM: S-adenosyl-L-homocysteine hydrolase, NAD binding domain; S-adenosyl-L-homocysteine hydrolase; TIGRFAM: adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (408 aa)    
Predicted Functional Partners:
Mpet_1893
COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: mem:Memar_2152 methionine synthase; PFAM: Methionine synthase vitamin-B12 independent; SPTR: Methionine synthase (B12-independent); PFAM: Cobalamin-independent synthase, Catalytic domain.
  
 
 0.983
Mpet_2163
DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR018117:IPR001525; KEGG: rci:RCIX2529 C-5 cytosine-specific DNA methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; SPTR: C-5 cytosine-specific DNA methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.920
Mpet_1603
Protein of unknown function DUF39; COGs: COG1900 conserved hypothetical protein; InterPro IPR016426:IPR002708:IPR000644; KEGG: mbn:Mboo_1272 hypothetical protein; PFAM: protein of unknown function DUF39; CBS domain containing protein; SMART: CBS domain containing protein; SPTR: Putative uncharacterized protein; PFAM: CBS domain; Domain of unknown function DUF39.
     
  0.900
Mpet_1604
InterPro IPR018449:IPR001450:IPR017900:IPR017896; KEGG: mpl:Mpal_1291 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; NIL domain; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S binding domain.
     
  0.900
Mpet_1242
COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342:IPR019811; KEGG: mem:Memar_0971 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; PRIAM: Homoserine dehydrogenase; SPTR: Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase.
  
 
 0.850
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
  
 
 0.736
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.734
Mpet_1704
COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR013196:IPR004143:IPR003142:IPR004408; KEGG: mem:Memar_1648 biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; Helix-turn-helix type 11 domain protein; biotin protein ligase domain protein; SPTR: Biotin--acetyl-CoA-carboxylase ligase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: HTH domain; Biotin protein ligase C terminal domain; Biotin/lipoate A/B protein ligase family; TIGRFAM: BirA biotin operon repressor domain; birA, biotin-[acetyl-CoA-carboxylase] ligase region.
     
 0.707
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.681
rpl2
Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
 
 0.659
Your Current Organism:
Methanolacinia petrolearia
NCBI taxonomy Id: 679926
Other names: M. petrolearia DSM 11571, Methanolacinia petrolearia DSM 11571, Methanoplanus petrolearius DSM 11571, Methanoplanus petrolearius SEBR 4847
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