node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alfi_0409 | Alfi_0412 | Alfi_0409 | Alfi_0412 | PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; Belongs to the transketolase family. | FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); TIGRFAM: trigger factor. | 0.483 |
Alfi_0409 | clpP | Alfi_0409 | Alfi_0411 | PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; Belongs to the transketolase family. | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.585 |
Alfi_0409 | clpX | Alfi_0409 | Alfi_0410 | PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; Belongs to the transketolase family. | Endopeptidase Clp ATP-binding regulatory subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.590 |
Alfi_0409 | guaB | Alfi_0409 | Alfi_2679 | PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; Belongs to the transketolase family. | Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.873 |
Alfi_0412 | Alfi_0409 | Alfi_0412 | Alfi_0409 | FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); TIGRFAM: trigger factor. | PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; Belongs to the transketolase family. | 0.483 |
Alfi_0412 | clpP | Alfi_0412 | Alfi_0411 | FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); TIGRFAM: trigger factor. | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.576 |
Alfi_0412 | clpX | Alfi_0412 | Alfi_0410 | FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); TIGRFAM: trigger factor. | Endopeptidase Clp ATP-binding regulatory subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.630 |
Alfi_0412 | ftsH | Alfi_0412 | Alfi_2469 | FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); TIGRFAM: trigger factor. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.445 |
Alfi_0412 | groS | Alfi_0412 | Alfi_0948 | FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); TIGRFAM: trigger factor. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.426 |
Alfi_1422 | clpX | Alfi_1422 | Alfi_0410 | Protease subunit of ATP-dependent protease; PFAM: Clp protease; Belongs to the peptidase S14 family. | Endopeptidase Clp ATP-binding regulatory subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.880 |
Alfi_1422 | groS | Alfi_1422 | Alfi_0948 | Protease subunit of ATP-dependent protease; PFAM: Clp protease; Belongs to the peptidase S14 family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.594 |
Alfi_1422 | guaB | Alfi_1422 | Alfi_2679 | Protease subunit of ATP-dependent protease; PFAM: Clp protease; Belongs to the peptidase S14 family. | Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.456 |
Alfi_1422 | lon | Alfi_1422 | Alfi_2458 | Protease subunit of ATP-dependent protease; PFAM: Clp protease; Belongs to the peptidase S14 family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.493 |
clpP | Alfi_0409 | Alfi_0411 | Alfi_0409 | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; Belongs to the transketolase family. | 0.585 |
clpP | Alfi_0412 | Alfi_0411 | Alfi_0412 | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); TIGRFAM: trigger factor. | 0.576 |
clpP | clpX | Alfi_0411 | Alfi_0410 | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Endopeptidase Clp ATP-binding regulatory subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.991 |
clpP | groS | Alfi_0411 | Alfi_0948 | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.728 |
clpP | guaB | Alfi_0411 | Alfi_2679 | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.456 |
clpP | lon | Alfi_0411 | Alfi_2458 | Protease subunit of ATP-dependent protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.493 |
clpX | Alfi_0409 | Alfi_0410 | Alfi_0409 | Endopeptidase Clp ATP-binding regulatory subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; Belongs to the transketolase family. | 0.590 |