STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa)    
Predicted Functional Partners:
Bcop_0677
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.997
Bcop_0135
COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006218:IPR020822:IPR002701; KEGG: bfs:BF3717 putative chorismate mutase; PFAM: DAHP synthetase I/KDSA; Chorismate mutase, type II; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SMART: Chorismate mutase; SPTR: Putative uncharacterized protein; IMG reference gene:2504105791; PFAM: Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase.
 
 
 0.993
Bcop_0685
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.964
Bcop_0763
Shikimate dehydrogenase substrate binding domain protein; COGs: COG0169 Shikimate 5-dehydrogenase; InterPro IPR013708:IPR006151; KEGG: bvu:BVU_2541 shikimate 5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase; SPTR: Shikimate 5-dehydrogenase; IMG reference gene:2504106451; PFAM: Shikimate dehydrogenase substrate binding domain; TIGRFAM: shikimate 5-dehydrogenase.
 
 0.957
Bcop_1421
COGs: COG1169 Isochorismate synthase; InterPro IPR004561:IPR015890; KEGG: pdi:BDI_1135 isochorismate synthase; PFAM: Chorismate binding, C-terminal; SPTR: Isochorismate synthase; TIGRFAM: Isochorismate synthase; IMG reference gene:2504107130; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases.
 
  
 0.936
Bcop_1814
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR006805:IPR015890; KEGG: aps:CFPG_020 anthranilate synthase component I; PFAM: Chorismate binding, C-terminal; Anthranilate synthase component I, N-terminal; PRIAM: Anthranilate synthase; SPTR: Anthranilate synthase component I; IMG reference gene:2504107530; PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region.
 
 
 0.927
Bcop_0011
Chorismate binding domain-containing protein; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR015890; KEGG: nis:NIS_0375 para-aminobenzoate synthase component I; PFAM: Chorismate binding, C-terminal; SPTR: Aminodeoxychorismate synthase subunit I; IMG reference gene:2504105666; PFAM: chorismate binding enzyme.
 
 
 0.926
Bcop_2386
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: bth:BT_1747 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyru [...]
   
 
 0.873
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.858
Bcop_0101
Beta-Ala-His dipeptidase; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR002933:IPR011650; KEGG: bth:BT_2085 putative succinyl-diaminopimelate desuccinylase; PFAM: Peptidase M20; Peptidase M20, dimerisation; PRIAM: Beta-Ala-His dipeptidase; SPTR: Putative uncharacterized protein; IMG reference gene:2504105757; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain.
     
 0.825
Your Current Organism:
Bacteroides coprosuis
NCBI taxonomy Id: 679937
Other names: B. coprosuis DSM 18011, Bacteroides coprosuis DSM 18011, Bacteroides coprosuis PC139, Bacteroides coprosuis str. DSM 18011, Bacteroides coprosuis strain DSM 18011
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.