| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bcop_0679 | Bcop_0680 | Bcop_0679 | Bcop_0680 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
| Bcop_0679 | Bcop_0681 | Bcop_0679 | Bcop_0681 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: zpr:ZPR_3635 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504106361; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.869 |
| Bcop_0679 | Bcop_0682 | Bcop_0679 | Bcop_0682 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | 0.405 |
| Bcop_0679 | Bcop_2386 | Bcop_0679 | Bcop_2386 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: bth:BT_1747 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyru [...] | 0.896 |
| Bcop_0679 | rnfB | Bcop_0679 | Bcop_2074 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | Electron transport complex, RnfABCDGE type, B subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. | 0.576 |
| Bcop_0680 | Bcop_0679 | Bcop_0680 | Bcop_0679 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | 0.999 |
| Bcop_0680 | Bcop_0681 | Bcop_0680 | Bcop_0681 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: zpr:ZPR_3635 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504106361; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.982 |
| Bcop_0680 | Bcop_0682 | Bcop_0680 | Bcop_0682 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | 0.412 |
| Bcop_0680 | Bcop_2386 | Bcop_0680 | Bcop_2386 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: bth:BT_1747 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyru [...] | 0.935 |
| Bcop_0680 | Bcop_2437 | Bcop_0680 | Bcop_2437 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; COGs: COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); InterPro IPR001450; KEGG: bvu:BVU_1755 NADH dehydrogenase I chain I; PFAM: 4Fe-4S binding domain; SPTR: NADH-quinone oxidoreductase subunit I; IMG reference gene:2504108169; PFAM: 4Fe-4S binding domain; TIGRFAM: NADH-quinone oxidoreductase, chain I. | 0.602 |
| Bcop_0680 | rnfB | Bcop_0680 | Bcop_2074 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Electron transport complex, RnfABCDGE type, B subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. | 0.905 |
| Bcop_0681 | Bcop_0679 | Bcop_0681 | Bcop_0679 | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: zpr:ZPR_3635 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504106361; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | 0.869 |
| Bcop_0681 | Bcop_0680 | Bcop_0681 | Bcop_0680 | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: zpr:ZPR_3635 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504106361; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.982 |
| Bcop_0681 | Bcop_0682 | Bcop_0681 | Bcop_0682 | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: zpr:ZPR_3635 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504106361; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | 0.412 |
| Bcop_0681 | Bcop_2386 | Bcop_0681 | Bcop_2386 | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: zpr:ZPR_3635 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504106361; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: bth:BT_1747 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyru [...] | 0.536 |
| Bcop_0682 | Bcop_0679 | Bcop_0682 | Bcop_0679 | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171:IPR004620; KEGG: chu:CHU_1435 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504106359; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | 0.405 |
| Bcop_0682 | Bcop_0680 | Bcop_0682 | Bcop_0680 | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.412 |
| Bcop_0682 | Bcop_0681 | Bcop_0682 | Bcop_0681 | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: zpr:ZPR_3635 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504106361; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.412 |
| Bcop_0682 | Bcop_0683 | Bcop_0682 | Bcop_0683 | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR002915; KEGG: bfs:BF3090 fructose-bisphosphate aldolase; PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; SPTR: Putative fructose-bisphosphate aldolase class I; IMG reference gene:2504106363; PFAM: DeoC/LacD family aldolase. | 0.504 |
| Bcop_0682 | Bcop_2386 | Bcop_0682 | Bcop_2386 | KEGG: cpi:Cpin_0931 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106362; PFAM: Uncharacterized protein family UPF0057. | COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: bth:BT_1747 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyru [...] | 0.461 |