STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisIPhosphoribosyl-ATP pyrophosphatase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit; In the C-terminal section; belongs to the PRA-PH family. (456 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.999
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR005861:IPR004839; KEGG: pdi:BDI_0968 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: Histidinol-phosphate aminotransferase; IMG reference gene:2504106656; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase [...]
 
 0.999
hisB
COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807:IPR013954:IPR005954:IPR006543; KEGG: chu:CHU_1270 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: Imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; PRIAM: Histidinol-phosphatase; SPTR: Histidine biosynthesis bifunctional protein HisB (Histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase); TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; IMG reference gene:2504106657; PFAM: [...]
 
 
 0.999
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; InterPro IPR023016:IPR006062; KEGG: dfe:Dfer_4238 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamin [...]
 
0.999
Bcop_1025
COGs: COG0560 Phosphoserine phosphatase; InterPro IPR002912:IPR005834:IPR004469:IPR006383; KEGG: bfs:BF2389 putative phosphoserine phosphatase; PFAM: Haloacid dehalogenase-like hydrolase; Amino acid-binding ACT; PRIAM: Phosphoserine phosphatase; SPTR: Putative phosphoserine phosphatase; TIGRFAM: Phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB, PSPase-like; IMG reference gene:2504106727; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB.
  
  
 0.999
Bcop_1211
Threonine-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: bfr:BF2490 aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Threonine-phosphate decarboxylase; SPTR: Aminotransferase involved in cobalamin biosynthesis CobC; IMG reference gene:2504106914; PFAM: Aminotransferase class I and II.
 
 
 0.999
Bcop_1603
Hypothetical protein; InterPro IPR013954; KEGG: pan:PODANSg1088 hypothetical protein; SPTR: Predicted CDS Pa_5_2490; IMG reference gene:2504107318; PFAM: Polynucleotide kinase 3 phosphatase; TIGRFAM: DNA 3'-phosphatase; HAD-superfamily hydrolase, subfamily IIIA.
  
 
 0.996
Bcop_0625
CoA-disulfide reductase; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterPro IPR013027:IPR004099:IPR001455:IPR001763; KEGG: bfs:BF0525 putative pyridine nucleotide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; SirA-like; PRIAM: CoA-disulfide reductase; SMART: Rhodanese-like; SPTR: Pyridine nucleotide-disulphide oxidoreductase; IMG reference gene:2504106303; PFAM: Pyridine nucleotide-disulphide oxidoreductase; SirA-like protein; Pyridine nucleotide-disulphide oxidoreductase, dimerisati [...]
  
  
 0.993
Bcop_0638
COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: bfs:BF0558 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Aspartokinase/homoserine dehydrogenase, threonine-sensitive; TIGRFAM: Aspartate kinase domain; IMG reference gene:2504106317; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid ki [...]
  
  
 0.991
Your Current Organism:
Bacteroides coprosuis
NCBI taxonomy Id: 679937
Other names: B. coprosuis DSM 18011, Bacteroides coprosuis DSM 18011, Bacteroides coprosuis PC139, Bacteroides coprosuis str. DSM 18011, Bacteroides coprosuis strain DSM 18011
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