STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Bcop_1000HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG0637 phosphatase/phosphohexomutase; InterPro IPR005834:IPR006402; KEGG: bth:BT_0697 putative phosphatase/phosphohexomutase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Hydrolase, CbbY/CbbZ/GpH/YieH family; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2504106702; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. (213 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
  0.684
Bcop_2154
Kojibiose phosphorylase; COGs: COG1554 Trehalose and maltose hydrolase (possible phosphorylase); InterPro IPR005195; KEGG: fjo:Fjoh_4428 glycoside hydrolase family protein; PFAM: Glycoside hydrolase, family 65, central catalytic; PRIAM: Kojibiose phosphorylase; SPTR: Candidate alpha glycoside phosphorylase; Glycoside hydrolase family 65; IMG reference gene:2504107875; PFAM: Glycosyl hydrolase family 65, N-terminal domain; Glycosyl hydrolase family 65 central catalytic domain.
 
 
 0.642
Bcop_0600
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
    
  0.638
Bcop_1233
Competence/damage-inducible protein CinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008135:IPR020817:IPR008136:IPR001453; KEGG: bfs:BF2511 putative competence-damage inducible; PFAM: CinA, C-terminal; Molybdopterin binding; SMART: Molybdopterin binding; SPTR: CinA-like protein; TIGRFAM: Competence-induced protein CinA; Molybdenum cofactor synthesis; CinA, C-terminal; IMG reference gene:2504106937; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-ter [...]
    
  0.629
Bcop_0535
D-lactate dehydrogenase (cytochrome); COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113; KEGG: bfs:BF0370 putative FAD-binding oxidoreductase; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: Putative uncharacterized protein; IMG reference gene:2504106209; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain.
    
  0.618
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.607
Bcop_2453
HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG0637 phosphatase/phosphohexomutase; InterPro IPR006402:IPR005834; KEGG: bfr:BF3814 putative beta-phosphoglucomutase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Putative beta-phosphoglucomutase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2504108185; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED.
  
  
 
0.584
hisB
COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807:IPR013954:IPR005954:IPR006543; KEGG: chu:CHU_1270 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: Imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; PRIAM: Histidinol-phosphatase; SPTR: Histidine biosynthesis bifunctional protein HisB (Histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase); TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; IMG reference gene:2504106657; PFAM: [...]
    
 0.580
Bcop_2155
Alpha amylase catalytic region; COGs: COG0366 Glycosidase; InterPro IPR006047:IPR006589; KEGG: sma:SAV_1307 oligo-1,6-glucosidase; PFAM: Glycosyl hydrolase, family 13, catalytic domain; SMART: Glycosyl hydrolase, family 13, subfamily, catalytic domain; SPTR: Putative uncharacterized protein; IMG reference gene:2504107876; PFAM: Alpha amylase, catalytic domain.
 
 
 0.573
Bcop_1391
COGs: COG0296 1 4-alpha-glucan branching enzyme; InterPro IPR004193:IPR006047:IPR006048:IPR006589; KEGG: bfs:BF2338 putative hydrolase; PFAM: Alpha-amylase, C-terminal all beta; Glycosyl hydrolase, family 13, catalytic domain; Glycoside hydrolase, family 13, N-terminal; PRIAM: 1,4-alpha-glucan branching enzyme; SMART: Glycosyl hydrolase, family 13, subfamily, catalytic domain; SPTR: Putative uncharacterized protein; IMG reference gene:2504107100; PFAM: Alpha amylase, C-terminal all-beta domain; Carbohydrate-binding module 48 (Isoamylase N-terminal domain); Alpha amylase, catalytic domain.
 
 
 0.561
Your Current Organism:
Bacteroides coprosuis
NCBI taxonomy Id: 679937
Other names: B. coprosuis DSM 18011, Bacteroides coprosuis DSM 18011, Bacteroides coprosuis PC139, Bacteroides coprosuis str. DSM 18011, Bacteroides coprosuis strain DSM 18011
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