| node1 | node2 | node1 annotation | node2 annotation | score |
| Bcop_0159 | Bcop_1003 | Biotin/lipoyl attachment domain-containing protein; COGs: COG1566 Multidrug resistance efflux pump; InterPro IPR000089; KEGG: bfs:BF3760 hypothetical protein; PFAM: Biotin/lipoyl attachment; SPTR: Putative uncharacterized protein; IMG reference gene:2504105815; PFAM: HlyD family secretion protein. | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | 0.400 |
| Bcop_0658 | Bcop_1003 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | 0.481 |
| Bcop_0680 | Bcop_0836 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: bth:BT_0249 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; SPTR: 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; IMG reference gene:2504106525. | 0.872 |
| Bcop_0680 | Bcop_1003 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | 0.504 |
| Bcop_0836 | Bcop_0680 | KEGG: bth:BT_0249 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; SPTR: 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; IMG reference gene:2504106525. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.872 |
| Bcop_0836 | Bcop_1003 | KEGG: bth:BT_0249 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; SPTR: 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; IMG reference gene:2504106525. | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | 0.504 |
| Bcop_1001 | Bcop_1002 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR007197:IPR010723:IPR004558; KEGG: bfr:BF1914 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504106704; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.980 |
| Bcop_1001 | Bcop_1003 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | 0.852 |
| Bcop_1001 | Bcop_1004 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | COGs: COG1629 Outer membrane receptor protein mostly Fe transport; InterPro IPR012910:IPR000531; KEGG: bfr:BF1916 putative TonB-dependent outer membrane protein; PFAM: TonB-dependent receptor, beta-barrel; TonB-dependent receptor, plug; SPTR: Putative uncharacterized protein; IMG reference gene:2504106706; PFAM: TonB dependent receptor; TonB-dependent Receptor Plug Domain. | 0.798 |
| Bcop_1002 | Bcop_1001 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR007197:IPR010723:IPR004558; KEGG: bfr:BF1914 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504106704; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.980 |
| Bcop_1002 | Bcop_1003 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR007197:IPR010723:IPR004558; KEGG: bfr:BF1914 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504106704; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | 0.878 |
| Bcop_1002 | Bcop_1004 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR007197:IPR010723:IPR004558; KEGG: bfr:BF1914 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504106704; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COGs: COG1629 Outer membrane receptor protein mostly Fe transport; InterPro IPR012910:IPR000531; KEGG: bfr:BF1916 putative TonB-dependent outer membrane protein; PFAM: TonB-dependent receptor, beta-barrel; TonB-dependent receptor, plug; SPTR: Putative uncharacterized protein; IMG reference gene:2504106706; PFAM: TonB dependent receptor; TonB-dependent Receptor Plug Domain. | 0.820 |
| Bcop_1003 | Bcop_0159 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | Biotin/lipoyl attachment domain-containing protein; COGs: COG1566 Multidrug resistance efflux pump; InterPro IPR000089; KEGG: bfs:BF3760 hypothetical protein; PFAM: Biotin/lipoyl attachment; SPTR: Putative uncharacterized protein; IMG reference gene:2504105815; PFAM: HlyD family secretion protein. | 0.400 |
| Bcop_1003 | Bcop_0658 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.481 |
| Bcop_1003 | Bcop_0680 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.504 |
| Bcop_1003 | Bcop_0836 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | KEGG: bth:BT_0249 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; SPTR: 5-methyltetrahydrofolate--homocysteine methyltransferase or methionine synthase; IMG reference gene:2504106525. | 0.504 |
| Bcop_1003 | Bcop_1001 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.852 |
| Bcop_1003 | Bcop_1002 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR007197:IPR010723:IPR004558; KEGG: bfr:BF1914 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504106704; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.878 |
| Bcop_1003 | Bcop_1004 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | COGs: COG1629 Outer membrane receptor protein mostly Fe transport; InterPro IPR012910:IPR000531; KEGG: bfr:BF1916 putative TonB-dependent outer membrane protein; PFAM: TonB-dependent receptor, beta-barrel; TonB-dependent receptor, plug; SPTR: Putative uncharacterized protein; IMG reference gene:2504106706; PFAM: TonB dependent receptor; TonB-dependent Receptor Plug Domain. | 0.875 |
| Bcop_1003 | Bcop_1089 | Major facilitator superfamily MFS_1; InterPro IPR011701; KEGG: bfs:BF1985 putative transmembrane transporter protein; PFAM: Major facilitator superfamily MFS-1; SPTR: Putative uncharacterized protein; IMG reference gene:2504106705; PFAM: Major Facilitator Superfamily. | COGs: COG3005 Nitrate/TMAO reductase membrane-bound tetraheme cytochrome c subunit; InterPro IPR005126:IPR017571; KEGG: pgn:PGN_1745 putative NapC/NirT cytochrome c-type protein; PFAM: NapC/NirT cytochrome c, N-terminal; SPTR: Quinol oxidase; TIGRFAM: Cytochrome c nitrate reductase, small subunit; IMG reference gene:2504106791; PFAM: NapC/NirT cytochrome c family, N-terminal region; TIGRFAM: cytochrome c nitrate reductase, small subunit. | 0.424 |