STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (367 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.999
Bcop_1657
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
Bcop_1651
COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: pdi:BDI_2071 acetohydroxyacid synthase small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Putative uncharacterized protein; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2504107367; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit.
 
 0.997
Bcop_1652
Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; IMG reference gene:2504107368; PFAM: Thiamine pyr [...]
 
 0.995
Bcop_1655
(R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SPTR: 2-isopropylmalate synthase LeuA; IMG reference gene:2504107371; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.975
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 0.972
ilvD
COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: pdi:BDI_2073 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; IMG reference gene:2504107369; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.952
Bcop_0081
COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804; KEGG: bth:BT_2071 isocitrate dehydrogenase [NADP]; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; IMG reference gene:2504105737; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type.
  
 0.927
Bcop_0080
COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: bfs:BF3541 citrate synthase; PFAM: Citrate synthase-like; SPTR: Citrate synthase; IMG reference gene:2504105736; PFAM: Citrate synthase; Belongs to the citrate synthase family.
 
 0.923
Bcop_2386
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: bth:BT_1747 pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyru [...]
  
 
 0.910
Your Current Organism:
Bacteroides coprosuis
NCBI taxonomy Id: 679937
Other names: B. coprosuis DSM 18011, Bacteroides coprosuis DSM 18011, Bacteroides coprosuis PC139, Bacteroides coprosuis str. DSM 18011, Bacteroides coprosuis strain DSM 18011
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