Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Bcop_2103ATP-binding region ATPase domain protein; COGs: COG0326 Molecular chaperone HSP90 family; InterPro IPR003594; KEGG: rpa:RPA0369 aminoacyl-tRNA synthetase, class I:ATP-binding region, ATPase-like; PFAM: ATPase-like, ATP-binding domain; SPTR: Aminoacyl-tRNA synthetase, class I:ATP-binding region, ATPase-like; IMG reference gene:2504107824; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (859 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 0.909
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 0.890
Bcop_1646
KEGG: pdi:BDI_0754 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504107362.
   
 0.791
Bcop_0918
KEGG: bvu:BVU_2152 fusion protein; SPTR: Conserved hypothetical fusion protein; IMG reference gene:2504106614.
  
 0.785
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 0.785
Bcop_1768
Conserved hypothetical protein CHP02687; InterPro IPR014060:IPR013973; KEGG: cpb:Cphamn1_1676 PglZ domain protein; PFAM: PglZ domain; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP02687; IMG reference gene:2504107484; PFAM: PglZ domain; TIGRFAM: TIGR02687 family protein.
   
 0.755
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
   
 
 0.692
Bcop_1537
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: bfr:BF2410 ATP-dependent Clp protease; PFAM: ATPase, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATP-dependent Clp protease; IMG reference gene:2504107252; PFAM: AAA domain (Cdc48 subfamily); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; UvrB/uvrC motif; ATPase family associated with various cellular activit [...]
  
 
 0.665
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.663
Bcop_1112
AAA ATPase central domain protein; COGs: COG0464 ATPase of the AAA+ class; InterPro IPR003593:IPR003959; KEGG: pmz:HMPREF0659_A5347 ATPase, AAA family; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; SPTR: ATPase, AAA family; IMG reference gene:2504106814; PFAM: ATPase family associated with various cellular activities (AAA).
  
 0.657
Your Current Organism:
Bacteroides coprosuis
NCBI taxonomy Id: 679937
Other names: B. coprosuis DSM 18011, Bacteroides coprosuis DSM 18011, Bacteroides coprosuis PC139, Bacteroides coprosuis str. DSM 18011, Bacteroides coprosuis strain DSM 18011
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