STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nfoEndonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (278 aa)    
Predicted Functional Partners:
Bcop_2219
2-alkenal reductase; COGs: COG2130 Putative NADP-dependent oxidoreductase; InterPro IPR013149:IPR020843; KEGG: sli:Slin_3139 alcohol dehydrogenase zinc-binding domain protein; PFAM: Alcohol dehydrogenase, C-terminal; PRIAM: 2-alkenal reductase; SMART: Polyketide synthase, enoylreductase; SPTR: Alcohol dehydrogenase zinc-binding domain protein; IMG reference gene:2504107940; PFAM: Zinc-binding dehydrogenase.
  
    0.768
Bcop_1247
KEGG: mba:Mbar_A1825 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504106951.
    
 0.710
Bcop_1470
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR000097:IPR004808:IPR005135; KEGG: bth:BT_0630 exodeoxyribonuclease; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Exodeoxyribonuclease; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; IMG reference gene:2504107181; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
    
 0.710
Bcop_2059
Endonuclease/exonuclease/phosphatase; COGs: COG0708 Exonuclease III; InterPro IPR005135; KEGG: phe:Phep_1385 endonuclease/exonuclease/phosphatase; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Endonuclease/exonuclease/phosphatase; IMG reference gene:2504107778; PFAM: Endonuclease/Exonuclease/phosphatase family.
    
 0.710
Bcop_0411
InterPro IPR014127; KEGG: fjo:Fjoh_2453 hypothetical protein; PFAM: Conserved hypothetical protein CHP02757; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP02757; IMG reference gene:2504106074; PFAM: Protein of unknown function (DUF2400); TIGRFAM: TIGR02757 family protein.
  
 
 0.573
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.573
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 
 0.541
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 
 0.535
Bcop_1576
NGG1p interacting factor 3 protein, NIF3; COGs: COG3323 conserved hypothetical protein; InterPro IPR002678; KEGG: bfs:BF2473 hypothetical protein; PFAM: NGG1p interacting factor 3, NIF3; SPTR: Putative uncharacterized protein; TIGRFAM: NGG1p interacting factor 3, NIF3; IMG reference gene:2504107291; PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: dinuclear metal center protein, YbgI/SA1388 family; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
     
 0.505
Bcop_2216
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR003148; KEGG: bfs:BF1194 putative K+/Na+ uptake protein; PFAM: Regulator of K+ conductance, N-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504107937; PFAM: TrkA-N domain.
  
  
 0.503
Your Current Organism:
Bacteroides coprosuis
NCBI taxonomy Id: 679937
Other names: B. coprosuis DSM 18011, Bacteroides coprosuis DSM 18011, Bacteroides coprosuis PC139, Bacteroides coprosuis str. DSM 18011, Bacteroides coprosuis strain DSM 18011
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