close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hcaF3-phenylpropionate dioxygenase, beta subunit; This operon in E. coli encodes a pathway for catabolism of aromatic acids; annotation transferred from E. coli. (188 aa)    
Predicted Functional Partners:
hcaE
3-phenylpropionate dioxygenase, alpha subunit; Annotation transferred from E. coli, perhaps 3-phenylpropionic acid breakdown cf PMID: 9603882.
 
 
 0.982
hcaC
Ferredoxin subunit of phenylpropionate dioxygenase; Annotation transferred from E. coli.
 
 
 0.971
hcaB
2,3-dihydroxy-2,3-dihydrophenylpropionatedehydr og enase; Annotation transferred from E. coli; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.964
CBG68673.1
Oxidoreductase alpha subunit.
 
 
 0.871
mhpB
2,3-dihydroxyphenylpropionate 1,2-dioxygenase; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family.
 
   
 0.853
CBG71437.1
Putative oxidoreductase.
 
 
 0.850
SCAB_6871
Putative ring hydroxylating dioxygenase subunit.
  
 
 0.839
SCAB_7051
[2Fe-2S] protein.
  
 
 0.839
CBG71301.1
Conserved hypothetical protein.
  
 
 0.829
crtV
Putative iron-sulfur protein; PMID:10767533; PMID:11200234; PMID:15716454; carotenoid pigment gene cluster.
  
 
 0.829
Your Current Organism:
Streptomyces scabiei
NCBI taxonomy Id: 680198
Other names: S. scabiei 87.22, Streptomyces scabiei 87.22, Streptomyces scabiei str. 87.22, Streptomyces scabiei strain 87.22
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.