Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
whiB-5Putative DNA-binding protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (122 aa)    
Predicted Functional Partners:
rpoC
DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.846
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.845
rbpA-2
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
  
 
 
 0.840
CBG70172.1
Conserved hypothetical protein.
       0.797
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
 
   0.785
CBG72054.1
Putative transcriptional regulator.
    
 
 0.769
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.753
CBG70174.1
Conserved hypothetical protein.
       0.732
hrdB
Major vegetative sigma factor HrdB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
    
 
 0.708
hrdD
Sigma factor HrdD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
    
 
 0.708
Your Current Organism:
Streptomyces scabiei
NCBI taxonomy Id: 680198
Other names: S. scabiei 87.22, Streptomyces scabiei 87.22, Streptomyces scabiei str. 87.22, Streptomyces scabiei strain 87.22
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.